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Is it Safe to do Endometrial Injury in the Same ICSI Cycle: A Randomized Controlled Trial

Infertility Clinical Trial

Official title:
Is it Safe to do Endometrial Injury in the Same ICSI Cycle: A Randomized Controlled Trial

Clinical Trial Summary

Endometrial injury is one of the interventions suggested to improve the endometrial receptivity by enhancing the decidualization process, and so increasing the pregnancy rate

Clinical Trial Description

In assisted reproductive techniques , specially ICSI, several approaches have been put forward to improve the endometrium, including endometrial injection of granulocyte colony-stimulating factor or platelet-rich plasma. Endometrial injury is one of the interventions suggested to improve the endometrial receptivity. Endometrial injury, also known as endometrial scratching, is the intentional damage of the endometrium, usually using a pipelle, aiming at increasing the implantation rate. The exact mechanism of action is still vague ,many hypotheses have been advocated, including enhanced decidualization, which is stimulated by the local injury. Moreover, endometrial injury stimulates an inflammatory response, which in turn adjusts gene expression. The value of endometrial injury is a controversial issue, there is no agreement on the exact time to perform endometrial scratching, so in the current study, we investigated the safety and efficacy of performing endometrial injury in the follicular phase of the same ICSI cycle. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05987995
Study type Interventional
Source Alexandria University
Contact
Status Completed
Phase N/A
Start date September 11, 2022
Completion date January 20, 2023
View Details
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