Impact of Serum Progesterone Levels on the Day of Fresh and Frozen Embryo Transfer on the Ongoing Pregnancy Rates.

Infertility Clinical Trial

Official title:

Impact of Serum Progesterone Levels on the Day of Fresh and Frozen Embryo Transfer on the Ongoing Pregnancy Rates

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04839627
• Other study ID #: PROGESTE
• Status: Completed
• Start date: June 16, 2021
• Est. completion date: June 1, 2023

Study information

• Verified date: July 2023
• Source: Hospital St. Joseph, Marseille, France
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Serum progesterone levels prepare the endometrium for implantation and play an important role during embryo transfer (ET). In clinical practice, luteal phase support progesterone supplementation is systematically offered to all women undergoing medically assisted procreation (AMP), independently of ET conditions (fresh and frozen).

The investigators propose to perform a prospective cross-sectional single-center cohort study to measure progesterone levels on the day of the ET on all AMP cycles and to compare these levels between active pregnancies and ET unsuccessful cycles. They will determine progesterone threshold levels corresponding to successful attempts in all ET strategies (fresh and frozen) as well as clinical and biological risk factors leading to luteal phase deficiency during ET. They could therefore individualize progesterone supplementation according to patient's needs.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 250
• Est. completion date: June 1, 2023
• Est. primary completion date: June 1, 2023
• Accepts healthy volunteers: No
• Gender: Female
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Age = 18 years

• planned embryo transfer

• signed informed consent

Exclusion Criteria:

• patients falsely included, major inclusion criteria not respected

• lack of social insurance

• refusal to participate in the research

Related Conditions & MeSH terms

• Infertility

Intervention

Other:
• serum progesterone measurement
progesterone levels measurement on the day of the embryo transfer on all AMP cycles

Locations

Country	Name	City	State
France	Hopital Saint Joseph Marseille	Marseille

Sponsors (1)

Lead Sponsor	Collaborator
Hospital St. Joseph, Marseille, France

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Serum progesterone levels on the day of embryo transfer	µg/L	During the procedure
Secondary	pregnancy rate	Post-embryo transfer ßHCG levels (UI/l).	1 month after procedure