Infertility Clinical Trial
Official title:
Effects of E2 (Estradiol), P4 (Progesterone) and LH Levels on the Day of Transfer and Endometrial Cavity Thickness on Implantation Success in Patients With Frozen-thawed Embryo Transfer Cycle: Prospective Data Analysis
Verified date | January 2022 |
Source | Bezmialem Vakif University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Thanks to recent advances in clinical practice and laboratory, embryo cryopreservation has become the first-line procedure in assisted reproductive technology. Embryo freezing process; Prevention of ovarian hyperstimulation syndrome is becoming an accepted practice for a growing number of indications, including preimplantation genetic testing (PGT), late follicular phase progesterone elevation, and embryo-endometrial asynchrony. Progesterone; plays a key role in the preparation of the endometrial cavity for embryo attachment. Supplementary progesterone preparations can be used to prevent luteal phase defects and provide progesterone support during cycle preparations for frozen-thawed embryo transfer. Our aim in this study is to show the effect of serum progesterone level on pregnancy outcomes on the day of embryo transfer.
Status | Completed |
Enrollment | 238 |
Est. completion date | November 21, 2021 |
Est. primary completion date | November 21, 2021 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Female |
Age group | 18 Years to 41 Years |
Eligibility | Inclusion Criteria: - body mass index (BMI) =25 kg/m2 - between 18 and 41 years old and with FSH levels on cycle day 3 of =12 mIU/ml Exclusion Criteria: - patients with uncorrected intracavitary structural uterine anomalies including unicornuate, bicornuate or didelphic uterus - recurrent miscarriage - presence of hydrosalpinx - cycle cancelation |
Country | Name | City | State |
---|---|---|---|
Turkey | Acibadem Kozyatagi Hospital | Istanbul | |
Turkey | Bezmialem Foundation University | Istanbul |
Lead Sponsor | Collaborator |
---|---|
Bezmialem Vakif University |
Turkey,
Gardner DK, Lane M. Culture and selection of viable blastocysts: a feasible proposition for human IVF? Hum Reprod Update. 1997 Jul-Aug;3(4):367-82. Review. — View Citation
Loutradi KE, Kolibianakis EM, Venetis CA, Papanikolaou EG, Pados G, Bontis I, Tarlatzis BC. Cryopreservation of human embryos by vitrification or slow freezing: a systematic review and meta-analysis. Fertil Steril. 2008 Jul;90(1):186-93. Epub 2007 Nov 5. — View Citation
Rienzi L, Gracia C, Maggiulli R, LaBarbera AR, Kaser DJ, Ubaldi FM, Vanderpoel S, Racowsky C. Oocyte, embryo and blastocyst cryopreservation in ART: systematic review and meta-analysis comparing slow-freezing versus vitrification to produce evidence for t — View Citation
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Primary | Pregnancy rates | Pregnancy rates of the participants | average of 1 year |
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