A Proof of Concept Study of Serum Progesterone Levels for IVF/ICSI

Status Completed

Clinical Trial Summary

This study will determine the rise of progesterone levels after human chorionic gonadotrophin (hCG) trigger in stimulated cycles IVF/ICSI

Clinical Trial Description

Studies have suggested that controlled ovarian hyperstimulation adversely affects endometrial receptivity. In ovarian stimulation cycles with exogenous gonadotrophins there is an ongoing debate regarding the effect of a late follicular phase progesterone level on reproductive outcomes. It is not yet clarified if an elevated serum progesterone level in the late follicular phase is a symptom or cause of an adverse effect on reproductive outcomes. A new hypothesis is evolving and gaining momentum providing a novel explanation for the association between late follicular phase progesterone rise and reproductive outcome. It is proposed that exogenous FSH (Follicle-stimulating hormone) administration results in supraphysiological levels of FSH, which induce an abundance of LH (luteinizing hormone) receptors on granulosa cells causing the follicles to become hypersensitive to LH-like activity (ie hCG trigger). Based on this hypothesis, the focus should be placed on the hCG trigger rather than on the late follicular phase progesterone rise. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04417569
Study type	Observational
Source	ART Fertility Clinics LLC
Contact
Status	Completed
Phase
Start date	February 4, 2021
Completion date	June 30, 2021

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A Proof of Concept Study of Serum Progesterone Levels for IVF/ICSI Following HCG Trigger for Oocyte Maturation

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms