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NCT04125017 Clinical Trial

Atrificial Shrinkage of Blastocyst Before In Vitro Fertilization

Infertility Clinical Trial

Official title:
Comparative Study Between Two Techniques for Artificial Shrinkage of Blastocysts Prior to Vitrification: LASER Pulse Versus Micro-needle Technique in Increasing Chemical, Clinical Pregnancy and Live Birth Rates After ICSI

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT04125017
Other study ID # blastocyst preparation
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date January 1, 2019
Est. completion date February 5, 2020

Study information
Verified date October 2023
Source Aljazeera Hospital
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Vitrification is a modern cryopreservation technique based on sudden cooling of reproductive cells to a temperature of -196 ° C in seconds that produces glass-like solidification of a solution without crystallization, but by extreme elevation in viscosity during freezing

Description:

Vitrification is a modern cryopreservation technique based on sudden cooling of reproductive cells to a temperature of -196 ° C in seconds that produces glass-like solidification of a solution without crystallization, but by extreme elevation in viscosity during freezing Unlike the slow freezing method, vitrification has better results in a complete elimination of ice crystal inside the cells as well as in the surrounding solution -Also, it has a significantly higher post-thawing survival rate in comparison to slow freezing method

Recruitment information / eligibility
Status Completed
Enrollment 409
Est. completion date February 5, 2020
Est. primary completion date January 4, 2020
Accepts healthy volunteers No
Gender Female
Age group 20 Years to 44 Years
Eligibility Inclusion Criteria: - women with infertility from 20 to 44 years Exclusion Criteria: - women with age more than 44 or less than 20

Study Design

Related Conditions & MeSH terms

Intervention

Device:
• ICSI with laser pulse
Using laser pulse before ICSI
• ICSI with micro needle technique
Using micro needle technique before ICSI

Locations
Country Name City State
Egypt Adam Giza

Sponsors (2)
Lead Sponsor Collaborator
Aljazeera Hospital Adam International Hospital

Country where clinical trial is conducted

Egypt, 

Outcome
Type Measure Description Time frame Safety issue
Primary The number of women who will have positive pregnancy test The number of women who will come pregnant after each technique 2 months
See also
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Completed NCT03623659 - pArtiaL zonA pelluciDa Removal by assisteD hatchINg of Blastocysts N/A
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Completed NCT03678584 - Supplementing Intracytoplasmic Sperm Injection Handling Medium With Chaetoglobosin A ( ICSI-CA) N/A
Completed NCT03678571 - Oocyte Vitrification Aided With Latrunculin A N/A
Completed NCT03678558 - Oocyte Vitrification Aided With Cytochalasin B N/A
Completed NCT03678818 - Supplementing Intracytoplasmic Sperm Injection Handling Medium With Latrunculin A (ICSI-LA) N/A
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