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NCT03953859 Clinical Trial

Embryo DNA Repair Capacity Project

Infertility Clinical Trial

Official title:
Investigation of Cellular DNA Repair Capacity in Human Preimplantation Embryos

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT03953859
Other study ID # RMA-UK-01
Secondary ID
Status Completed
Phase
First received
Last updated
Start date April 4, 2019
Est. completion date December 9, 2021

Study information
Verified date January 2022
Source Reproductive Medicine Associates of New Jersey
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The mail aim of the present study is to use molecular methods to analyze the ability of human preimplantation embryos to repair their DNA

Description:

The main aim of the present study is to investigate the DNA repair pathways of preimplantation embryos, examining the events that take place following induction of a DSB at a unique targeted site. The investigators aim to address questions concerning the functionality of the DNA repair mechanism(s) in developing embryos, before and after genome activation.

Recruitment information / eligibility
Status Completed
Enrollment 6
Est. completion date December 9, 2021
Est. primary completion date April 30, 2020
Accepts healthy volunteers
Gender All
Age group 21 Years to 42 Years
Eligibility Inclusion Criteria: - gamete donors: be at least 21 years of age, in good health and eligible to donate their games through the standard gamete donation programs - IVF couples: any couples proceeding with a routine IVF cycle Exclusion Criteria: - less than 21 years of age - inability to provide informed consent

Study Design

Related Conditions & MeSH terms

Intervention

Genetic:
• double strand break
an induction of a double strand break will be made in the embryos generated for this research and the repair mechanism observed

Locations
Country Name City State
United States Reproductive Medicine Assoicates of New Jersey Basking Ridge New Jersey

Sponsors (1)
Lead Sponsor Collaborator
Reproductive Medicine Associates of New Jersey

Country where clinical trial is conducted

United States, 

Outcome
Type Measure Description Time frame Safety issue
Primary repair of double strand break in DNA targeted deep sequencing to identify the presence of the double strand break in the DNA and subsequent repair ability of the embryo up to 12 days
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