Clinical Trials Logo
  1. Home
  2. Infertility
  3. NCT03953859
  4. Details
NCT03953859 Clinical Trial

Embryo DNA Repair Capacity Project

Infertility Clinical Trial

Official title:
Investigation of Cellular DNA Repair Capacity in Human Preimplantation Embryos

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT03953859
Other study ID # RMA-UK-01
Secondary ID
Status Completed
Phase
First received
Last updated
Start date April 4, 2019
Est. completion date December 9, 2021

Study information
Verified date January 2022
Source Reproductive Medicine Associates of New Jersey
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The mail aim of the present study is to use molecular methods to analyze the ability of human preimplantation embryos to repair their DNA

Description:

The main aim of the present study is to investigate the DNA repair pathways of preimplantation embryos, examining the events that take place following induction of a DSB at a unique targeted site. The investigators aim to address questions concerning the functionality of the DNA repair mechanism(s) in developing embryos, before and after genome activation.

Recruitment information / eligibility
Status Completed
Enrollment 6
Est. completion date December 9, 2021
Est. primary completion date April 30, 2020
Accepts healthy volunteers
Gender All
Age group 21 Years to 42 Years
Eligibility Inclusion Criteria: - gamete donors: be at least 21 years of age, in good health and eligible to donate their games through the standard gamete donation programs - IVF couples: any couples proceeding with a routine IVF cycle Exclusion Criteria: - less than 21 years of age - inability to provide informed consent

Study Design

Related Conditions & MeSH terms

Intervention

Genetic:
• double strand break
an induction of a double strand break will be made in the embryos generated for this research and the repair mechanism observed

Locations
Country Name City State
United States Reproductive Medicine Assoicates of New Jersey Basking Ridge New Jersey

Sponsors (1)
Lead Sponsor Collaborator
Reproductive Medicine Associates of New Jersey

Country where clinical trial is conducted

United States, 

Outcome
Type Measure Description Time frame Safety issue
Primary repair of double strand break in DNA targeted deep sequencing to identify the presence of the double strand break in the DNA and subsequent repair ability of the embryo up to 12 days
See also
  Status Clinical Trial Phase
Completed NCT03607409 - Role of Inhibin A as Biomarker for Ovarian Response for IVF Treatment
Recruiting NCT02312076 - GnRHa for Luteal Phase Support in Long GnRHa Protocol Cycles Phase 4
Terminated NCT02161861 - Improvement of IVF Fertilization Rates, by the Cyclic Tripeptide FEE - Prospective Randomized Study N/A
Completed NCT03287479 - Comparison of a Semi-automated Closed Vitrification System (Gavi®) With a Manual Open Vitrification Sytem (Cryotop®) N/A
Terminated NCT03522350 - Randomized Trial Comparing EmbryoScope With EmbryoScope+. N/A
Completed NCT04496284 - Embryo Transfer Outcomes After Vitrification With Slush Nitrogen Compared to Liquid Nitrogen N/A
Completed NCT03623659 - pArtiaL zonA pelluciDa Removal by assisteD hatchINg of Blastocysts N/A
Completed NCT03895099 - New Ovarian Stimulation With Random Start, Use of Progestin Protocol for Oocyte Donors Phase 3
Active, not recruiting NCT04142112 - Randomized, Standard-Controlled, Study to Evaluate the Ohana IVF Sperm Preparation Kit, SPeRtility IVF Next Generation N/A
Completed NCT03152643 - Cumulative Live Birth Rates After Cleavage-stage Versus Blastocyst-stage Embryo Transfer N/A
Recruiting NCT03683771 - Assessment of Endometrial Pattern and Sub-endometrial Vascularity in ICSI Outcome
Recruiting NCT03161119 - Comparing Two Different Embryo Transfer Catheters N/A
Completed NCT04108039 - Micronized Progesterone vs Gonadotropin-releasing Hormone (GnRH) Antagonist in Freeze-all IVF Cycles. N/A
Completed NCT03678571 - Oocyte Vitrification Aided With Latrunculin A N/A
Completed NCT03677492 - Supplementing Intracytoplasmic Sperm Injection Handling Medium With Cytochalasin D ( ICSI-CD) N/A
Completed NCT03678818 - Supplementing Intracytoplasmic Sperm Injection Handling Medium With Latrunculin A (ICSI-LA) N/A
Completed NCT03678584 - Supplementing Intracytoplasmic Sperm Injection Handling Medium With Chaetoglobosin A ( ICSI-CA) N/A
Completed NCT03678558 - Oocyte Vitrification Aided With Cytochalasin B N/A
Completed NCT03678597 - Supplementing Intracytoplasmic Sperm Injection Handling Medium With Latrunculin B ( ICSI-LB) N/A
Completed NCT03678610 - Handling Medium for ICSI With Ionomycin and Latrunculin A N/A