Infertility Clinical Trial
— RES-OHSSOfficial title:
Resveratrol as a Preventive Treatment of Ovarian Hyperstimulation Syndrome
Verified date | August 2018 |
Source | IVI Madrid |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Evaluation of resveratrol treatment oh ovarian hyperstimulation syndrome in egg donors
Status | Completed |
Enrollment | 70 |
Est. completion date | June 1, 2019 |
Est. primary completion date | October 1, 2018 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Female |
Age group | 18 Years to 35 Years |
Eligibility |
Inclusion Criteria: - Number of follicles greater than 12 mm after ovarian stimulation - Number of retrieved oocytes greater than 21 Exclusion Criteria: - >35 years-old - PCOS - Endometriosis - Systemic pathology - Positive serologies for HBV, HBC and HIV - Abnormal karyotype |
Country | Name | City | State |
---|---|---|---|
Spain | Ivi Madrid | Madrid |
Lead Sponsor | Collaborator |
---|---|
IVI Madrid |
Spain,
Basini G, Tringali C, Baioni L, Bussolati S, Spatafora C, Grasselli F. Biological effects on granulosa cells of hydroxylated and methylated resveratrol analogues. Mol Nutr Food Res. 2010 Jul;54 Suppl 2:S236-43. doi: 10.1002/mnfr.200900320. — View Citation
Ortega I, Villanueva JA, Wong DH, Cress AB, Sokalska A, Stanley SD, Duleba AJ. Resveratrol reduces steroidogenesis in rat ovarian theca-interstitial cells: the role of inhibition of Akt/PKB signaling pathway. Endocrinology. 2012 Aug;153(8):4019-29. doi: 10.1210/en.2012-1385. Epub 2012 Jun 19. — View Citation
Ortega I, Wong DH, Villanueva JA, Cress AB, Sokalska A, Stanley SD, Duleba AJ. Effects of resveratrol on growth and function of rat ovarian granulosa cells. Fertil Steril. 2012 Dec;98(6):1563-73. doi: 10.1016/j.fertnstert.2012.08.004. Epub 2012 Sep 6. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Serum VEGF levels | Serum determination of VEGF levels | 1 day | |
Secondary | Hemoconcentration | Volume of red blood cells measured in percentage | 1 day | |
Secondary | Serum estradiol levels | Serum determination of estradiol levels asessed in picograms per mililiter | 1 day | |
Secondary | Ascitis | Volume of liquid in Douglas pouch asessed in mililiters | 1 day |
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