Infertility Clinical Trial
Official title:
Estradiol, Progesterone and Endometrial Thickness in Frozen Euploid Embryo Transfer
The development and improvement in Preimplantation genetic diagnosis/screening (PGS) in
association with the efficacy and security of vitrification and trophectoderm biopsy, more
efficient stimulation schemes and laboratory improvements in culture and embryo selection
have contributed to high success of the assisted reproductive technologies(ART). Transferring
an euploid embryo avoids one of the main reasons of miscarriage and implantation failure (
Rubio et al, 22016) and overcomes one of the most important confounding factors. Usually, the
transfer of euploid embryos is performed under standard hormone replacement therapy (HRT) and
are referred to as FET-PGS cycles( Frozen embryo transfer). The study of FET-PGS cycles with
the transfer of a single euploid blastocyst is the best model for evaluation of the impact of
the endometrial preparation . Among factors influencing FET outcomes, patient's age,
endometrial preparation, endometrium thickness, endometrial pattern, number and quality of
embryos transferred , difficulty at ET, recently P4 have received more attention .
The importance of Progesterone (P4) in embryo implantation has been widely studied. P4 plays
an important role in endometrial gland formation, embryonic implantation and pregnancy
maintenance, both in natural and artificial cycles.
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