Infertility Clinical Trial
Official title:
The Early Luteal Progesterone Profile in IVF Patients Triggered With hCG
Verified date | August 2019 |
Source | Vietnam National University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Until now very little information exists regarding the early luteal serum progesterone profile after Human chorionic gonadotropin (hCG) trigger. This pilot study will help characterize the serum progesterone, 17-hydroxyprogesterone profiles in IVF patients and correlate progesterone, 17-Hydroxyprogesterone levels to ovarian follicles obtained after stimulation with exogenous gonadotropins.
Status | Completed |
Enrollment | 161 |
Est. completion date | August 8, 2017 |
Est. primary completion date | August 8, 2017 |
Accepts healthy volunteers | No |
Gender | Female |
Age group | 18 Years to 42 Years |
Eligibility |
Inclusion Criteria: - Freeze all cycle after hCG trigger - Age 18 - 38 - BMI < 28kg/m2 - Normal ovarian reserve, defined by Anti-Mullerian Hormone (AMH) > 1.25 ng/ml or Antral Follicle Count (AFC) = 6 measured within two months prior to stimulation start - Receiving gonadotrophin releasing hormone (GnRH) antagonist co-treatment during ovarian stimulation - Agreement to participate in the study, and to disclose any medical events to the investigator. The subject must be willing and able to comply with the protocol requirements for the duration of the study. - Have given written informed consent with the understanding that the subject may withdraw consent at any time without prejudice to future medical care. Exclusion Criteria: - Previous poor response (= 3 oocytes) after high dose follicle stimulating hormone (FSH) stimulation - Hyper-response defined as >20 follicles = 14 mm - Chronical medical conditions like Diabetes, Crohns disease, Thyroid disease, Hepatitis B and Sexually Transmitted Diseases Simultaneous participation in an interventional clinical trial. |
Country | Name | City | State |
---|---|---|---|
Vietnam | My Duc Hospital | Ho Chi Minh City |
Lead Sponsor | Collaborator |
---|---|
Vietnam National University | M? Ð?c Hospital |
Vietnam,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Serum concentrations of progesterone,17-Hydroxyprogesterone, LH, E2, and hCG during early luteal phase | Blood samples are collected at ten points of time. | In 6 days after human chorionic gonadotropin injection | |
Secondary | Number of follicles = 11 mm luteal phase | Number of follicles are counted by ultrasound. | On the day of hCG injection |
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