Anti-Müllerian Hormone is Not Predictive of Pregnancy in Donor Insemination Cycles in Non-infertile Women

Infertility Clinical Trial

Official title:

Ovarian Reserve Does Not Predict Pregnancy in Non-Infertile Women: An Assessment Using the Donor Sperm Insemination Model

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03160872
• Other study ID #: SMD-2016-033
• Status: Completed
• Phase: N/A
• First received: May 18, 2017
• Last updated: May 18, 2017
• Start date: January 1, 2013
• Est. completion date: December 15, 2016

Study information

• Verified date: May 2017
• Source: Institut Universitari Dexeus
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

To evaluate if ovarian reserve (measured by means of anti-mullerian hormone -AMH- and antral follicle count -AFC-) can predict pregnancy in donor insemination cycles (dIUI) performed in non-infertile women.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 143
• Est. completion date: December 15, 2016
• Est. primary completion date: June 30, 2016
• Accepts healthy volunteers: No
• Gender: Female
• Age group: 18 Years to 43 Years

Eligibility

Inclusion Criteria:

• absence of male partner

• complete azoospermia or the presence of a genetic condition in the partner that made the couple opt for donor sperm

• absence of previous history of infertility.

• d ta on AMH and AFC assessment before the first dIUI cycle.

Exclusion Criteria:

• previous history of infertility.

• Presence of any gynaecological condition that could impair the inseminations results:

• endometriosis, hydrosalpinx,…

Related Conditions & MeSH terms

• Infertility

Intervention

Diagnostic Test:
• Anti Mullerian Hormone Measurement
Anti Mullerian Hormone was measured in all patients within two months before the first insemination cycle

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Institut Universitari Dexeus

References & Publications (3)

Catteau-Jonard S, Roux M, Dumont A, Delesalle AS, Robin G, Dewailly D. Anti-Müllerian hormone concentrations and parity in fertile women: the model of oocyte donors. Reprod Biomed Online. 2017 May;34(5):541-545. doi: 10.1016/j.rbmo.2017.02.010. Epub 2017 Mar 1. — View Citation

Hvidman HW, Bentzen JG, Thuesen LL, Lauritsen MP, Forman JL, Loft A, Pinborg A, Nyboe Andersen A. Infertile women below the age of 40 have similar anti-Müllerian hormone levels and antral follicle count compared with women of the same age with no history of infertility. Hum Reprod. 2016 May;31(5):1034-45. doi: 10.1093/humrep/dew032. Epub 2016 Mar 9. — View Citation

Somigliana E, Lattuada D, Colciaghi B, Filippi F, La Vecchia I, Tirelli A, Baffero GM, Paffoni A, Persico N, Bolis G, Fedele L. Serum anti-Müllerian hormone in subfertile women. Acta Obstet Gynecol Scand. 2015 Dec;94(12):1307-12. doi: 10.1111/aogs.12761. Epub 2015 Sep 16. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Clinical Pregnancy	Clinical Pregnancy evaluated by ultrasound with fetal heart beat	6 weeks after insemination procedure
Secondary	Miscarriage rate	Number of clinical miscarriage after clinical pregnancy	Evaluated until 15 weeks after insemination procedure

External Links

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