Infertility Clinical Trial
Official title:
Cumulative Live Birth Rates in Patients With Repeated Implantation Failure (RIF) Undergoing Preimplantation Genetic Screening (PGS )
This is a single centre retrospective study in repeated implantation failure patients: < 39
years old, at least 4 D3 good quality embryos or 2 good quality blastocysts transferred
without implantation, absence of known causes of implantation failures (uterine
malformation, thrombophilia, severe male factor, uncontrolled thyroid disfunction,
autoimmune disease).
Patients scheduled for PGS underwent one or more stimulation cycles (oocyte or blastocyst
banking) in order to maximize chances of embryo transfer. PGS cycles are analyzed globally.
Aditionally, PGS cycles with a single stimulation cycle are analyzed in comparison to
standard IVF cycles.
Status | Completed |
Enrollment | 80 |
Est. completion date | December 2016 |
Est. primary completion date | December 2016 |
Accepts healthy volunteers | No |
Gender | Female |
Age group | 18 Years to 38 Years |
Eligibility |
Inclusion criteria: - women < 39 years - repeated implantation failure: at least 4 day 3 good quality embryos or 2 good quality blastocysts transferred without implantation Exclusion criteria: - partner with severe male factor, or abnormal sperm Fluorescence in situ hybridization (FISH) analysis - presence of uni or bilateral hydrosalpinx, uterine malformation, thrombophilia, uncontrolled thyroid disfunction or autoimmune disease |
Observational Model: Cohort, Time Perspective: Retrospective
Country | Name | City | State |
---|---|---|---|
Spain | Departamento de Ginecología Obstetricia y Reproducción. Hospital Universitari Dexeus | Barcelona |
Lead Sponsor | Collaborator |
---|---|
Institut Universitari Dexeus |
Spain,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Cumulative live birth rate | at 24 months of first embryo transfer | No | |
Secondary | Clinical Pregnancy Rate | 6 weeks after embryo transfer | No | |
Secondary | Implantation Rate | 6 weeks after embryo transfer | No | |
Secondary | Miscarriage Rate | Until 20 weeks after embryo transfer | No |
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