Infertility Clinical Trial
Official title:
Reducing the Impact of Ovarian Stimulation - The RIOT Project. Study RIOT-A: The Role of Aromatase Inhibitor in Reducing the Detrimental Effects of Ovarian Stimulation to Optimize Outcomes in Fresh Embryo Transfer Cycles
This project seeks to determine whether estradiol suppression achieved with adjuvant treatment with an aromatase inhibitor improves end-follicular and midluteal phase parameters during IVF. 128 patients will be randomized to either placebo or active treatment.
The aim of the study is to investigate whether the detrimental effects of ovarian stimulation
on outcomes in fresh embryo transfer cycles be ameliorated by co-treatment with aromatase
inhibitors? The research questions are:
1. Can the impact of ovarian stimulation on late follicular phase sex steroid levels (and
hence endometrial receptivity) be mitigated by co-treatment with aromatase inhibitors
during ovarian stimulation?
2. Does co-treatment with aromatase inhibitors 'normalize' the endocrinology of the
midluteal phase
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