Infertility Clinical Trial
Official title:
Random-start Ovarian Stimulation in Egg-donors (ROSE) Trial: a Self-controlled Study
The purpose of this prospective single-center study is to evaluate the laboratory outcome after random start ovarian stimulation in oocyte donors. The study will be performed in egg-donors but this type of treatment has the potential to be implemented in general infertility population.
The study group will start ovarian stimulation randomly in different moments throughout the
menstrual cycle.
Randomization will take place on day 2-3 of the menstrual cycle, according to a list of
random allocation of treatments and egg-donors will be assigned to random start ovarian
stimulation: During follicular phase starting at day 5,7,9,11 or 13 of the menstrual cycle
and during luteal phase starting at luteinizing hormone (LH) peak +3,+5,+7,+9 or +11.
Egg-donors will receive urinary follicle stimulating hormone (FSH) 150-225 IU/d in
gonadotropin-releasing hormone (GnRH) antagonist protocol with cetrorelix acetate 0,25 mg/d
starting five days after ovarian stimulation and a GnRH agonist trigger with triptorelin 0,2
mg to induce the final follicular maturation. Transvaginal ultrasound and serum analysis
(estradiol, progesterone, LH and FSH) will be included for cycle monitoring.
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