Infertility Clinical Trial
Official title:
A Randomised Trial to Compare Antral Follicle Count and Serum Anti-Mullerian Hormone Level for Determination of Gonadotrophin Dosing in In-vitro Fertilisation
NCT number | NCT02739269 |
Other study ID # | UW 12-358 |
Secondary ID | |
Status | Completed |
Phase | N/A |
First received | |
Last updated | |
Start date | April 7, 2016 |
Est. completion date | April 20, 2018 |
Verified date | February 2019 |
Source | The University of Hong Kong |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
This is a prospective randomized trial to compare the use of AFC and serum AMH as the basis
for gonadotrophin dosing in in-vitro fertilization treatment.
The hypothesis is that the use of serum AMH as the criterion for determination of
gonadotrophin dosing in IVF treatment results in more optimal ovarian response than AFC.
Status | Completed |
Enrollment | 200 |
Est. completion date | April 20, 2018 |
Est. primary completion date | April 20, 2018 |
Accepts healthy volunteers | No |
Gender | Female |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - Subjects undergoing the first IVF cycle during the study period. Exclusion Criteria: - Body mass index >=30 kg/m2 - Subjects in repeated IVF cycles - Subjects undergoing IVF treatment using donor oocytes - Subjects undergoing pre-implantation genetic diagnosis |
Country | Name | City | State |
---|---|---|---|
Hong Kong | Queen Mary Hospital | Hong Kong |
Lead Sponsor | Collaborator |
---|---|
The University of Hong Kong |
Hong Kong,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Percentage of Subjects Having Desired Ovarian Response | Percentage of subjects with number of oocytes retrieved being between 6 and14 | One single time point, i.e. at the time of oocyte retrieval | |
Secondary | Percentage of Subjects Requiring Step-up or Step-down of Gonadotrophin Dose Upon First Ultrasound Tracking | The dose of gonadotrophin will be adjusted according to the ovarian response: if 5 or less follicles growing beyond 10 mm --> step up if more than 15 follicles growing beyond 10 mm --> step down | 8th day of ovarian stimulation |
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