Infertility Clinical Trial
Official title:
Morphometrics and Morphokinetics of Thawed Oocytes and Embryos
Verified date | December 2015 |
Source | Katholieke Universiteit Leuven |
Contact | n/a |
Is FDA regulated | No |
Health authority | Belgium: Ethics Committee |
Study type | Observational |
The aim of this observational study is to describe for the first time a complete set of
morphometric and morphokinetic parameters of frozen-thawed human embryos in order to select
the embryo with the highest implantation potential. These parameters will be correlated with
(1) data of the fresh embryos and their subsequent survival, the evolution of the contact
surfaces between surviving blastomeres and the resumption of mitosis; (2) patient
characteristics and clinical outcome of frozen-thawed embryos and (3) a comparison between
embryos cryopreserved with vitrification or the slow method regarding these parameters will
be performed.
This project aims to introduce new evaluation criteria of the frozen-thawed embryos to
improve success rate of FET cycles. By establishing new precise, reliable and non-invasive
measurable parameters, we aim to (1) select which supernumerary embryos are at chance to
survive the freezing/thawing procedures, (2) establish cut off parameters for the survival
rate of the embryo, (3) assess implantation, pregnancy and live birth rates depending on the
developmental characteristics after thawing and after 24h of culture.
Our strategy for improving the outcome of FET cycles is based on the study of morphometric
and morphokinetic parameters in frozen-thawed embryos and the correlation with
embryological, clinical and cycle parameters. Transferring a well-defined thawed embryo with
a high implantation potential may lead towards an increase in the implantation and life
birth rate and an increase in the cumulative live birth rate with a reduction of the IVF
costs in order to optimize the health-economic situation of reproductive medicine.
Status | Completed |
Enrollment | 1272 |
Est. completion date | December 2015 |
Est. primary completion date | December 2014 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Female |
Age group | 18 Years to 40 Years |
Eligibility |
Inclusion Criteria: - patients with female age < 40 years at Oocyte retrieval Exclusion Criteria: - Patients with female age >40 years at Oocyte retrieval - cycles with Preimplantation genetic diagnosis - donated gametes |
Observational Model: Cohort, Time Perspective: Retrospective
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
Sophie Debrock |
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | embryo implantation (measured by the number of intrauterine fetal sacs on ultrasound per number of embryos transferred) after a thawing / warming cycle | 6-7 weeks | No |
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