Infertility Clinical Trial
Official title:
Dual Trigger Versus Booster Dose of HCG on Ovum Pickup Day in Antagonist IVF/ICSI Cycles Triggered With GnRH Agonist in High Responder Females to Salvage the Luteal Phase
Verified date | January 2018 |
Source | Cairo University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
To salvage the luteal phase and improve pregnancy rate in antagonist IVF/ICSI cycles triggered with GnRH agonist. Two strategies are compared dual trigger with GnRH agonist plus 1000 IU of HCG or triggering with GnRH and giving a booster dose of HCG (1500 IU) on the day of ovum pickup.
Status | Completed |
Enrollment | 200 |
Est. completion date | January 2018 |
Est. primary completion date | January 2018 |
Accepts healthy volunteers | No |
Gender | Female |
Age group | 20 Years to 37 Years |
Eligibility |
Inclusion Criteria: - High responder females undergoing antagonist protocol IVF/ICSI cycle - More than 14 MII oocytes - Estradiol more than 3500 pg/ml on day of trigger Exclusion Criteria: - Any other protocol - Normal or poor responders |
Country | Name | City | State |
---|---|---|---|
Egypt | IVF centre, Obstetrics and Gynaecology Department, Cairo University Hospitals (Kasr EL Aini) | Cairo | |
Egypt | Adam International hospital | Giza | |
Egypt | Nile IVF center | Giza |
Lead Sponsor | Collaborator |
---|---|
Cairo University | Adam International Hospital, Nile Ivf Center, Cairo, Egypt |
Egypt,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Other | Chemical pregnancy rate | The numbr of cycles with a positive pregnancy test after 14 days from embryo transfer | 1 year | |
Other | Early miscarriage rate | Pregnancies ending with miscarriage before 12 weeks of gestation | 1 year | |
Other | Ongoing pregnancy rate | Pregnancies ongoing beyond 12 weeks of gestation | 1 year | |
Other | Live birth rate | Pregnancies ending in a live birth | 1 year | |
Primary | Clinical pregnancy rate | The number of cycles with a evidence of a gestational sac with fetal pulstaions after 5 weeks from pregnancy test | 1 year | |
Secondary | OHSS rate | The number of cycles with evidence of OHSS | 1 year |
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