Infertility Clinical Trial
Official title:
Low-dose Growth Hormone Supplementation Increases Clinical Pregnancy Rate in Poor Responders Undergoing in Vitro Fertilisation.
Verified date | May 2017 |
Source | Centro de Infertilidad y Reproducción Humana |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The objective of this study is to assess whether a low dose of GH supplementation (0.5 IU/day) increases clinical pregnancy rates in women with a history of POR who failed to become pregnant in two previous IVF cycles.
Status | Completed |
Enrollment | 64 |
Est. completion date | May 2017 |
Est. primary completion date | December 2016 |
Accepts healthy volunteers | No |
Gender | Female |
Age group | 18 Years to 50 Years |
Eligibility |
Inclusion Criteria: - Women with a history of POR, defined according to the Bologna criteria - Absence of pregnancy in at least two previous IVF cycles Exclusion Criteria: - Body mass index = 30 kg/m2 - Presence of endocrinopathies - Altered karyotype in one or both partners - History of invasive ovarian surgery - History of chronic, autoimmune or metabolic diseases - Altered meiosis in testicular biopsy or altered sperm-FISH - Drug therapy in the male partner - Participation, within the previous 6 months, in another clinical trial with medication |
Country | Name | City | State |
---|---|---|---|
Spain | Centro de Infertilidad y Reproducción Humana (CIRH) | Barcelona |
Lead Sponsor | Collaborator |
---|---|
Centro de Infertilidad y Reproducción Humana |
Spain,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Clinical pregnancy rate | Presence of an intrauterine gestational sac with embryonic cardiac activity display, evaluated by ultrasound | 7 weeks of gestation | |
Secondary | Retrieved oocytes | Total number of retrieved oocytes | On egg retrieval day | |
Secondary | Number of obtained embryos | Total number of obtained embryos | 3 days after egg retrieval | |
Secondary | Embryo quality | Total number of top quality embryos per cycle | 3 days after embryo transfer | |
Secondary | Proportion of cycles with embryo transfer | Proportion of cycles reaching embryo transfer per initiated cycle | 3 days after egg retrieval |
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