Infertility Clinical Trial
Official title:
Early Embryo Cleavage And Multiple Pregnancies After ICSI
To observe whether Number of early cleavage embryos can be a predictor for multiple pregnancies after ICSI.
A total of 193 infertile couples, attending the ART unit, International Islamic Center for
Population Studies and Research (IICPSR), -Al- Azhar University in the period from December
2010 to September 2012, were included in this study.
The controlled ovarian hyperstimulation protocol was performed according to a long GnRH
agonist protocol starting in the midluteal phase (day 21) of the preceding cycle. Embryos
were assessed at 25 - 27 hr after ICSI for early cleavage. Embryos which reached the two
cell stage at this interval were classified as Early Cleavage (EC) embryos, and the
remaining as Non Early Cleavage (NEC) embryos. Embryos were assessed again at 64 - 68 hours
post-ICSI for day-three embryo morphology. Day 3 embryo transfer was done. The best two or
three embryos, according to day 3 embryo morphology were transferred. The patients were
subdivided into two subgroups; one will transfer early cleavage embryos (EC) and the other
will transfer non early cleavage embryo (NEC).
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Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Screening
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