Gene Expression Analysis of the Endometrium After Endometrial Biopsy in Fertile Women

Infertility Clinical Trial

Official title:

Gene Expression Analysis of the Endometrium After Endometrial Biopsy in Fertile Women

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02219425
• Other study ID #: Miacol-2014-2H
• Status: Completed
• Phase: N/A
• First received: July 11, 2014
• Last updated: January 29, 2017
• Start date: June 2014
• Est. completion date: August 2016

Study information

• Verified date: August 2016
• Source: University of Aarhus
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The aim of this study is to evaluate the gene expression of the endometrium after an endometrial biopsy in fertile women using Next Generation Sequencing of total RNA.

Description:

An endometrial biopsy is done at cycle day LH+7 and repeated in the next cycle at cycle day LH+7.

Tissue is analysed and compared for changes in gene expression profile using Seq RNA

Recruitment information / eligibility

• Status: Completed
• Enrollment: 10
• Est. completion date: August 2016
• Est. primary completion date: August 2016
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Female
• Age group: 18 Years to 40 Years

Eligibility

Inclusion Criteria:

• Fertile women

• Age: 18-40 years

• BMI: 18-32

• Regular menstrual cycle

• No use of hormonal contraceptives or IUD the last 3 months

Exclusion Criteria:

• Patients in need of a interpreter

• Suspected intrauterine abnormalities

• Pregnancy

Related Conditions & MeSH terms

• Infertility

Intervention

Procedure:
• endometrial biopsy

Locations

Country	Name	City	State
Denmark	Fertility Clinic Horsens Hospital	Horsens

Sponsors (1)

Lead Sponsor	Collaborator
University of Aarhus

Country where clinical trial is conducted

Denmark, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Gene Expression of the Endometrium after an endometrial biopsy	An endometrial biopsy is done at cycle day LH+7 and repeated in the next cycle at cycle day LH+7.; Endometrial tissue is analysed for changes in gene expression profile of various chemokines and cytokines using RNA Sequencing technology	1 month between each biopsy