Infertility Clinical Trial
Women with low ovarian reserve typically respond less well to the drugs used to stimulate
the ovary during IVF treatment and produce fewer eggs and, as a result, are less likely to
fall pregnant either naturally or after fertility treatment. The ideal stimulation regimen
for poor responders is currently unknown.
Dehydroepiandrosterone (DHEA) has been reported to improve pregnancy chances for poor
responders, and is now utilized by approximately one third of all IVF centers world-wide.
However, the current clinical evidence for DHEA on improvement of ovarian response and IVF
outcome is insufficient. The validity of the results of the former studies, especially the
varied inclusion criteria used to specify poor responders, is a subject of debate. Recently
a uniform definition on poor ovarian response, the Bologna criteria, has been proposed by
the European Society for Human Reproduction and Embryology(ESHRE). However, no studies have
been performed study to evaluate the potential effects of DHEA supplementation according to
these standards.
The purpose of this study is to assess the impact of DHEA supplementation on IVF outcome of
poor ovarian responders that fulfill the Bologna criteria.
n/a
Observational Model: Cohort, Time Perspective: Retrospective
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