Infertility Clinical Trial
Official title:
In This Study, the Addition of rLH, Increasing the Dose of rFSH and the Control Groups Regarding the Results of IVF in These Patients.
The investigators aimed to evaluate patients who had In-vitro fertilization treatment and who had COH (controlled ovarian hyperstimulation) cycles applying long protocol with GnRH (gonadotropin-releasing hormone) analogue with suboptimal response to the rFSH. The investigators evaluated and compared the addition of rLH, increasing the dose of rFSH and the control groups regarding the results of IVF in these patients.
1. Aim
-We aimed to evaluate patients who had In-vitro fertilization treatment and who had COH
(controlled ovarian hyperstimulation) cycles applying long protocol with GnRH
(gonadotropin-releasing hormone) analogue with suboptimal response to the rFSH. We
evaluated and compared the addition of rLH, increasing the dose of rFSH and the control
groups regarding the results of IVF in these patients.
2. Material and Methods -Between 01.01.2009-30.04.2011, 137 patients presented with
infertility to the unit of Assisted Reproduction Techniques- of the Department of
Obstetrics and Gynecology- Meram Medical Faculty- Selcuk University and were planned
for ICSI-ET (intracytoplasmic sperm injection-embryo transfer) with normal ovarian
function, who had long protocol of GnRH analogue and COH (controlled ovarian
hyperstimulation) with rFSH were included in the study. 52 patients were considered
responsive to stimulation and composed the normal control group (Group 1). On the 7th
day of stimulation transvaginal ultrasonography was carried out. Patients who had at
least 6 follicles about 6-10mm but had no follicle above 10mm and E2 (Oestradiol) level
of <250 pg / ml were considered to have suboptimal response to stimulation and were
divided into two groups. For Group 2 (n = 50), 75IU / L rLH was added to the treatment,
for Group 3 (n = 35), 75IU / L of rFSH was added to the treatment. IVF results were
compared between the groups.
;
Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention
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