Infertility Clinical Trial
Official title:
Reduction of Sperm DNA Fragmentation by Oral Ginger (Zingiberofficinale) Extract Treatment
This study is a randomized, double blind, controlled clinical trials assess the efficacy of the ginger oral treatment on sperm DNA fragmentation, sperm parameters and male hormones.
Sperm DNA fragmentation is known to affect male fertility. Previous findings have suggested
the implication of oxidative stress in the etiology of this pathological condition. The
present study was designed to find out DNA fragmentation in ejaculated spermatozoa can be
reduced by oral treatment with Ginger extract. 71 men with unexplained or Idiopathic
infertility were randomized between a Ginger treatment (500 milligram daily for 3months)
group and a placebo group.
Sperm DNA fragmentation was evaluated by Terminal deoxyribonucleotidyltransferase-mediated
dUTP nick-end labeling assay (TUNEL) before and after treatment. No differences in basic
sperm parameters were found between the Ginger treatment and the placebo group before or
after treatment. However, the percentage of DNA-fragmented spermatozoa was markedly reduced
(P< .005) in the Ginger treatment group after the treatment as compared with the
pretreatment values). No difference in the pretreatment and post treatment incidence of
sperm DNA fragmentation was observed in the placebo group. These data show that sperm DNA
damage can be efficiently treated with oral Ginger extract administered during a relatively
short time period.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
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