Infertility Clinical Trial
Official title:
Intrauterine Injection of Human Chorionic Gonadotropin to Enhance Embryo Implantation
NCT number | NCT01986374 |
Other study ID # | HCG 2013 |
Secondary ID | |
Status | Completed |
Phase | N/A |
First received | |
Last updated | |
Start date | June 2013 |
Est. completion date | February 2016 |
Verified date | November 2013 |
Source | Servy Massey Fertility Insititute |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The endometrium is deprived of signals form the embryo in IVF conditions. Studies suggest that placing HCG into the uterus prior to embryo transfer can enhance implantation.
Status | Completed |
Enrollment | 75 |
Est. completion date | February 2016 |
Est. primary completion date | December 2015 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Female |
Age group | 21 Years to 47 Years |
Eligibility |
Inclusion Criteria: - infertility patients undergoing IVF with good expectation of two embryos day 3 or day 5. must speak and read English. Includes donor eggs. Exclusion Criteria:abnormal uterus - |
Country | Name | City | State |
---|---|---|---|
United States | Servy Massey Fertility Insititute | Atlanta | Georgia |
Lead Sponsor | Collaborator |
---|---|
Servy Massey Fertility Insititute |
United States,
Hong KH, Forman EJ, Werner MD, Upham KM, Gumeny CL, Winslow AD, Kim TJ, Scott RT Jr. Endometrial infusion of human chorionic gonadotropin at the time of blastocyst embryo transfer does not impact clinical outcomes: a randomized, double-blind, placebo-controlled trial. Fertil Steril. 2014 Dec;102(6):1591-5.e2. doi: 10.1016/j.fertnstert.2014.08.006. Epub 2014 Sep 16. — View Citation
Mansour R, Tawab N, Kamal O, El-Faissal Y, Serour A, Aboulghar M, Serour G. Intrauterine injection of human chorionic gonadotropin before embryo transfer significantly improves the implantation and pregnancy rates in in vitro fertilization/intracytoplasmic sperm injection: a prospective randomized study. Fertil Steril. 2011 Dec;96(6):1370-1374.e1. doi: 10.1016/j.fertnstert.2011.09.044. Epub 2011 Nov 1. — View Citation
Santibañez A, García J, Pashkova O, Colín O, Castellanos G, Sánchez AP, De la Jara JF. Effect of intrauterine injection of human chorionic gonadotropin before embryo transfer on clinical pregnancy rates from in vitro fertilisation cycles: a prospective study. Reprod Biol Endocrinol. 2014 Jan 29;12:9. doi: 10.1186/1477-7827-12-9. — View Citation
Zarei A, Parsanezhad ME, Younesi M, Alborzi S, Zolghadri J, Samsami A, Amooee S, Aramesh S. Intrauterine administration of recombinant human chorionic gonadotropin before embryo transfer on outcome of in vitro fertilization/ intracytoplasmic sperm injection: A randomized clinical trial. Iran J Reprod Med. 2014 Jan;12(1):1-6. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | HCG enhances pregnancy rate | compare pregnancy rates to established clinical norms. | 9 months. | |
Secondary | implantation rate | compare implantation rate per embryo to clinical norms. | 18 months | |
Secondary | ongoing pregnancy rate | compare success to clinical norms | 22 months |
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