Infertility Clinical Trial
Official title:
Prevalence of Chronic Endometritis in Patients With Recurrent Miscarriages or Repeated Implantation Failures in In-vitro Fertilization
Verified date | July 2015 |
Source | OVO R & D |
Contact | n/a |
Is FDA regulated | No |
Health authority | Canada: Health Canada |
Study type | Observational |
Chronic endometritis is a persistent inflammation of the endometrium. Chronic endometritis
is asymptomatic or little symptomatic. Sometimes, patient with chronic endometritis can have
genital bleeding, pelvic chronic pain, pain during sexual relations, persistent vaginal
white loosing. The hysteroscopy can detect the presence or absence of chronic endometritis.
Some studies showed that the endometritis could have an impact on the embryo implantation
and could explain recurrent miscarriages or repeated embryo implantation failures.
The goal of this study is to evaluate the frequency of the chronic endometritis in patients
with recurrent miscarriages or repeated embryo implantation failures
Status | Completed |
Enrollment | 100 |
Est. completion date | May 2015 |
Est. primary completion date | March 2014 |
Accepts healthy volunteers | No |
Gender | Female |
Age group | 18 Years to 45 Years |
Eligibility |
Inclusion Criteria: Group repeated miscarriages - Women aged 18 to 43 years - = 2 miscarriages before 14 weeks of gestation - Genetic (karyotype x2), thrombophilic and endocrine assessment should be completed Group of implantation failure in In-vitro fertilization - Women aged 18 to 45 years - Absence of pregnancy after 3 good quality embryos transferred in women under 35 years and 4 embryos in the 35 years and over. Exclusion Criteria: - Positive pregnancy test - Unexplained bleeding - Incomplete miscarriage assessment - Uterine malformation - Antibiotic treatment during or within one month prior to the biopsy |
Observational Model: Case-Only, Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
Canada | Clinique Ovo | Montreal | Quebec |
Lead Sponsor | Collaborator |
---|---|
OVO R & D |
Canada,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Rate of chronic endometritis | 1 day | No | |
Secondary | Pregnancy rate | 1 year | No |
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