The Clinical Impact of Selecting Acrosome Reacted Spermatozoa for ICSI

Status Withdrawn

Clinical Trial Summary

Presently spermatozoa for ICSI are selected based on morphology and motion, without determining if acrosome reaction (AR) had occurred during sperm preparation or not. Although not critical if the sperm is injected into the ooplasm, the occurrence of AR might might be an indicator of better spermatozoon quality and implantation potential, especially in severe OTA cases. It is impossible with conventional plain optic microscopy used in IVF units to determine in vivo (without fixation) if AR has occurred, and as a result spermatozoa are injected randomly. It is readily possible to distinguish AR+ from AR- spermatozoa using polarized light microscopy due to different bifriengance.

In this study the investigators seek to determine, by a prospective RCT, if selecting only acrosome reacted spermatozoa, in severe OTA cases, will improve the outcome of ICSI and the entire IVF process.

Clinical Trial Description

A prospective RCT to determine the effect of polscope based spermatozoa selection for ICSI. ;

Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Infertility

Clinical Trial Details

NCT number	NCT01594645
Study type	Interventional
Source	Hadassah Medical Organization
Contact
Status	Withdrawn
Phase	Phase 1
Start date	September 2012
Completion date	August 2015

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