Infertility Clinical Trial
Official title:
A New Tool for Automatic Ovarian Follicle Count and it Abilities to Evaluate Ovarian Reserve
The ultrasound unit in Meir Medical Center developed new software to automated ovarian
follicle count on the basis of 3D US. The investigators intent to evaluate this software at
two steps:
- To compared the abilities of the software to physician follicle count.
- To evaluate with the software the antral follicle count, as expression to ovarian
reserve at 3 different time of the month.
The investigators believe that the software measurement of the small follicle can be better
than the common antral follicle count that is use today, and by this accurate evaluation of
the small follicle the investigators can evaluate the ovarian reserve at any time of the
mount, and not only at the early follicular phase that use today.
Status | Not yet recruiting |
Enrollment | 50 |
Est. completion date | November 2013 |
Est. primary completion date | November 2013 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Female |
Age group | 18 Years to 40 Years |
Eligibility |
Inclusion Criteria: - woman under age 40 years all - woman at evaluation before beginning of fertility treatment - woman with regular menstrual cycle Exclusion Criteria: - woman who treat with ovulation induction |
Observational Model: Cohort, Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
Israel | Fertility unit, Meir Medical Center, Israel | Kfar Saba |
Lead Sponsor | Collaborator |
---|---|
Meir Medical Center |
Israel,
Al-Azemi M, Killick SR, Duffy S, Pye C, Refaat B, Hill N, Ledger W. Multi-marker assessment of ovarian reserve predicts oocyte yield after ovulation induction. Hum Reprod. 2011 Feb;26(2):414-22. doi: 10.1093/humrep/deq339. Epub 2010 Dec 8. — View Citation
Deb S, Jayaprakasan K, Campbell BK, Clewes JS, Johnson IR, Raine-Fenning NJ. Intraobserver and interobserver reliability of automated antral follicle counts made using three-dimensional ultrasound and SonoAVC. Ultrasound Obstet Gynecol. 2009 Apr;33(4):477-83. doi: 10.1002/uog.6310. — View Citation
Hendriks DJ, Kwee J, Mol BW, te Velde ER, Broekmans FJ. Ultrasonography as a tool for the prediction of outcome in IVF patients: a comparative meta-analysis of ovarian volume and antral follicle count. Fertil Steril. 2007 Apr;87(4):764-75. Epub 2007 Jan 18. — View Citation
Hendriks DJ, Mol BW, Bancsi LF, Te Velde ER, Broekmans FJ. Antral follicle count in the prediction of poor ovarian response and pregnancy after in vitro fertilization: a meta-analysis and comparison with basal follicle-stimulating hormone level. Fertil Steril. 2005 Feb;83(2):291-301. — View Citation
Hsu A, Arny M, Knee AB, Bell C, Cook E, Novak AL, Grow DR. Antral follicle count in clinical practice: analyzing clinical relevance. Fertil Steril. 2011 Feb;95(2):474-9. doi: 10.1016/j.fertnstert.2010.03.023. — View Citation
Murtinger M, Aburumieh A, Rubner P, Eichel V, Zech MH, Zech NH. Improved monitoring of ovarian stimulation using 3D transvaginal ultrasound plus automated volume count. Reprod Biomed Online. 2009 Nov;19(5):695-9. — View Citation
Olivennes F, Howies CM, Borini A, Germond M, Trew G, Wikland M, Zegers-Hochschild F, Saunders H, Alam V. Individualizing FSH dose for assisted reproduction using a novel algorithm: the CONSORT study. Reprod Biomed Online. 2011 Feb;22 Suppl 1:S73-82. doi: 10.1016/S1472-6483(11)60012-6. — View Citation
Raine-Fenning N, Jayaprakasan K, Clewes J. Automated follicle tracking facilitates standardization and may improve work flow. Ultrasound Obstet Gynecol. 2007 Dec;30(7):1015-8. — View Citation
Raine-Fenning N, Jayaprakasan K, Deb S, Clewes J, Joergner I, Dehghani Bonaki S, Johnson I. Automated follicle tracking improves measurement reliability in patients undergoing ovarian stimulation. Reprod Biomed Online. 2009 May;18(5):658-63. — View Citation
Styer AK, Toth TL. Antral follicle count in clinical practice: building the bridge from ovarian reserve to in vitro fertilization outcome. Fertil Steril. 2011 Feb;95(2):480-1; discussion 484-5. doi: 10.1016/j.fertnstert.2010.11.054. Epub 2010 Dec 23. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Antral follicle count accuracy during the menstrual cycle for ovarian reserve evaluation. | Within the 28-35 days of the menstrual cycle. | No |
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