Infertility Clinical Trial
Official title:
Comparison of Micro Dose Gonadotropin-Releasing Hormone (GnRH) Agonist Flare up & Flare Protocol in Poor Responders in Assisted Reproductive Technology (ART) Cycle
About 9 to 24 % of women undergoing in vitro fertilization (IVF) treatment respond poorly to the usual gonadotrophin stimulation protocol applied. Several induction ovulation treatments have been suggested for increasing pregnancy rate. In this study, the investigators will compare the outcome of Microflare protocol and Flare up regimen in poor responders.
In this randomized clinical trial study, a total of 200 infertile women with poor ovarian
response who undergo IVF / ICSI treatment cycle at Royan Institute will enroll in this study
and will randomly be divided into two groups of 100 patients. This study has been approved by
Royan ethics committee and written consent will be obtained from each patient.
The patients will be randomized to one of two groups of Flare Up or Microdose GnRh agonist
flare up.
Luteinizing Hormone (LH), Follicle Stimulating Hormone (FSH), Estradiol, will be evaluated on
day 2 or 3 and when follicle size become >14.
2 weeks after embryo transfer, the patients will be tested for serum β-hCG for assessing the
pregnancy. The clinical pregnancy will be clarified by the number of women with gestational
sacs on transvaginal sonography at 4-6 weeks of gestation. In the calculation of
implantation, the number of gestational sacs will be considered.
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