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Randomized Controlled Trial Comparing Slow-freezing to Vitrification of Oocytes

Infertility Clinical Trial

Official title:
Cryopreservation of Oocytes: A Randomized Controlled Trial Comparing Slow-freezing to Vitrification

Clinical Trial Summary

Preservation of fertility is limited. Current methods include embryo cryopreservation and while still experimental, ovarian cryopreservation. In single women who are at risk for infertility secondary to cancer or couples who have ethical reasons to avoid embryo cryopreservation, oocyte cryopreservation is an alternative Purpose of study is to compare slow freeze to vitrification of human oocytes. Successful cryopreservation and subsequent thawing programs are characterized by avoiding ice crystal formation.Vitrification, newer alternative to slow freeze method, process by which water is prevented from forming ice.

Our hypothesis is that higher survival rate per oocyte is to be expected in the vitrification group.

Clinical Trial Description

Although several reviews of smaller studies of cryoprotectant methodology exist randomized controlled trials,comparing slow-freeze-rapid-thaw procedure to vitrification of oocytes, are not available. The purpose of this study is to compare these two methods of oocyte cryopreservation in human oocytes. ;

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00777387
Study type Interventional
Source Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Contact
Status Terminated
Phase N/A
Start date August 2008
Completion date January 2014
View Details
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