Infertility Clinical Trial
Official title:
Evaluation of the Affects of an Oocyte Freezing and Thawing Technique in Patients Undergoing In-vitro Fertilization (IVF)
Over the past several decades, considerable effort has been expended toward the successful
cryopreservation of various human cells. While attempts at cryopreservation have been
directed at different tissue types, one of the most vigorously pursued targets has been
reproductive tissue. Historically, cryopreservation of human sperm has existed for several
decades. The earliest reports of pregnancies (Trounson et al., 1983) and births (Zeilmaker
et al., 1984) from the cryopreservation of human embryos occurred in the early 1980s.
Presently, the freezing and storage of human embryos following in vitro fertilization (IVF)
is standard practice at most fertility clinics. In 2003, the CDC Assisted Reproductive
Technology success rates report stated that 4,246 live births occurred out of 17,517
non-donor frozen embryo cycles. . Because the human egg is a relatively voluminous cell with
abundant cytoplasm, crystallization at the time of freezing may result in damage to the
organelles. Secondly, a mature metaphase II oocyte contains a fragile spindle apparatus
involved in cleavage.
The purpose of this research study is to evaluate a method of freezing and thawing oocytes.
This evaluation will be made by comparing the survival rates and rates of fertilization,
cleavage and embryo quality of fresh oocytes and frozen-thawed oocytes which will be
inseminated during the IVF (in vitro fertilization) treatment cycle. In addition, the same
comparisons will be made between frozen oocytes from infertile women and those of egg
donors. You are being asked to be in this study because you are currently undergoing in
vitro fertilization.
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Observational Model: Case Control, Time Perspective: Prospective
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