Infertility Clinical Trial
— LROfficial title:
A Randomized Controlled Trial of Microdose Leuprolide Protocol vs. Luteal Phase Ganirelix Protocol in Predicted Low Responders
Verified date | May 2018 |
Source | UConn Health |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
Patients who have undergone in vitro fertilization (IVF) and produced four or less follicles or had four or less oocytes (eggs) retrieved are often referred to as poor responders. We will refer to these patients from this point forward as "low responders" to avoid using a potentially offensive label. We are currently using 2 different IVF medication protocols in our practice to treat low responder patients with infertility: the "Microdose Leuprolide" protocol and the "Luteal Phase Ganirelix" protocol. We would like to conduct a randomized-controlled trial and randomize patients to one treatment group or the other to determine which medication protocol is more effective in treating infertility in this group of patients.
Status | Completed |
Enrollment | 54 |
Est. completion date | September 2010 |
Est. primary completion date | September 2010 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Female |
Age group | 21 Years to 44 Years |
Eligibility |
Inclusion Criteria: - Women ages 21-44 undergoing IVF for infertility - Prior IVF cycle with poor response (=4 follicles on ultrasound,= 4 oocytes retrieved, peak estradiol <1000 pg/mL, prior IVF cycle cancelled for poor response) OR - Predicted poor response (age >40, basal FSH =10 mIU/mL, prior poor response to gonadotropin (peak estradiol <500 pg/mL)) Exclusion Criteria: - Medical contraindications for oral contraceptive pills, injectable gonadotropin medications, estradiol, or progesterone in oil use. - Medical contraindications to pregnancy - Prior IVF cycle with Microdose Protocol or Luteal Phase Ganirelix Protocol |
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
UConn Health |
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Implantation rate | 4-6 weeks | ||
Secondary | Number of oocytes retrieved | 4-6 weeks |
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