Infertility Clinical Trial
Official title:
Study on the Effect of GnRH Antagonist on hCG Day on Outcomes of Controlled Ovarian Hyperstimulation With GnRH Antagonist Flexible Multiple-dose Protocols
Gonadotropin-releasing hormone (GnRH) antagonists have been widely used for the prevention
of premature luteinizing hormone (LH) surges during controlled ovarian hyperstimulation
(COH) for in vitro fertilization and embryo transfer (IVF-ET) since the late 1990's.
Many years have passed since GnRH antagonists were introduced to prevent premature LH surges
during stimulated cycles. However, there is still no consensus on the optimal GnRH
antagonist protocol. Attempts at modifying GnRH antagonist protocols have been made to
improve COH outcomes. However, a meta-analysis of 27 randomized controlled trials, including
recent reports, showed significantly lower clinical ongoing pregnancy rates in the
antagonist group. Thus, additional efforts are needed to identify the optimal stimulation
protocols to achieve better follicular and embryonic development and to improve the
pregnancy rates in COH using GnRH antagonist.
Given the assumption of a detrimental effect of GnRH antagonist on the pregnancy rate, with
current protocols, we hypothesized that a shorter duration of GnRH antagonist administration
might improve outcome.
n/a
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Single Blind (Caregiver), Primary Purpose: Treatment
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