Infertility Clinical Trial
Official title:
Temozolomide Induced Changes in Semen/Sperm Analysis in Men With Newly Diagnosed, Progressive or Recurrent Primary Malignant Brain Tumors
RATIONALE: Learning whether temozolomide changes semen or sperm in patients with brain
tumors may help doctors learn about the long-term effects of treatment and plan the best
treatment.
PURPOSE: This clinical trial is studying changes in semen or sperm caused by temozolomide in
patients with newly diagnosed, progressive, or recurrent primary malignant brain tumors.
OBJECTIVES:
Primary
- Assess if temozolomide induces any changes in standard semen or sperm analysis
parameters (i.e., volume, viscosity, pH, forward progression, total count, total motile
count, motility, presence of round cells, agglutination, and morphology) in patients
with newly diagnosed, recurrent, or progressive primary malignant brain tumors.
OUTLINE: This is a pilot study.
During treatment with temozolomide, patients undergo semen or sperm sample collection at
baseline, 3 months, and 6 months for semen analysis. Samples are analyzed for volume,
viscosity, pH, forward progression, total count, total motile count, motility, presence of
round cells, agglutination, and morphology.
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