Infertility Clinical Trial
Official title:
Blinded Randomised Trial About the Influence of Estradiol Supplementation During the Luteal in Patients Undergoing in Vitro Fertilization (IVF) Treatment
To evaluate whether treatment with Estradiol supplementation during the luteal phase
improves IVF outcomes
Patients undergoing IVF treatment with controlled ovarian hyperstimulation using a GnRH
analog will receive 4 mg estradiol valerate in the luteal phase.Patient's followup will
include E2 progesterone and BHCG 14 days after embryo transfer and vaginal ultrasound on day
21 and 28 after embryo transfer
The study will include Patients undergoing IVF treatment with controlled ovarian
hyperstimulation using a daily GnRH analog in a long protocol,older then 18, .The women will
be randomised to two groups.Both groups will be given vaginal tabs of natural micronized
progesterone(Uterogestan)
The study group will be given oral estradiol Valerate 4 mg.Prior to treatment, each patient
will be signed on informed concent.
Patients will be excluded if they are older than 40, have any systemic illnesses or a
personal or family history of a thromboembolic event.
Follow up:
Verification of pregnancy status and hormonal profile will be carried out on day fourteen
after embryo transfer by means of serum hCG,P and E2. clinical pregnancy will be defined as
the presence of a gestational sac on ultrasonography on day 21 after embryo transfer and
fetal heart will be evaluated on day 28
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Treatment
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