Infertility Clinical Trial
Official title:
Half-Dose Depot Triptorelin Versus Reduced-Dose Daily Buserelin in a Long Protocol of Controlled Ovarian Stimulation for ICSI/ET
The purpose of this study is to determine whether half-dose depot triptorelin are as effective as reduced-dose daily buserelin in the controlled ovarian stimulation for intracytoplasmic sperm injection and embryo transfer
Significant doubts remain about which type of GnRH agonists [GnRHa] administration to be
used in controlled ovarian stimulation [COS] cycles. The use of a single-dose depot
long-acting GnRHa instead of a daily low dose preparation would be more comfortable for
patients, however, inducing a profound pituitary desensitization, it increases the number of
gonadotropin ampoules and the duration of the COS cycle without improving pregnancy rates or
other clinical outcomes. Thus, some authors recommend a reduction of both dose and/or
duration of GnRHa administration. Halving the dose of depot triptorelin, for instance, has
been studied against its full dose administration since 1992 with rather similar clinical
outcomes. Half-dose depot leuprolide acetate has also resulted in comparable clinical
outcomes with standard daily injections in long GnRHa protocol. Reducing the daily doses of
short acting GnRHa has been advocated to demonstrate equivalent results to standard doses.
To our knowledge, however, the reduced daily doses have not been evaluated against half dose
depot forms in long GnRHa protocols.
Thus, we originally compared a half-dose depot triptorelin with reduced daily doses of
short-acting buserelin in a long protocol for intracytoplasmic sperm injection and embryo
transfer [ICSI/ET] cycles.
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Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Treatment
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