Infertility Clinical Trial
Official title:
Randomized Controlled Trial Comparing the Long GnRH Agonist Protocol and the Flexible GnRH Antagonist Protocol of Ovarian Stimulation in Normal Responders
The purpose of this study is to compare the efficacy of two controlled ovarian stimulation protocols, the GnRH agonist protocol, widely known as the "long" protocol, and the flexible GnRH antagonist protocol, in terms of pregnancy rates and embryological data, in infertile patients receiving IVF treatment.
Status | Recruiting |
Enrollment | 300 |
Est. completion date | June 2007 |
Est. primary completion date | |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Female |
Age group | 21 Years to 39 Years |
Eligibility |
Inclusion Criteria: - Age 18-39 years - Body mass index 18-29 kg/m2 - Menstrual cycle from 24-35 days - Normal basal FSH (<10 IU/ml) - Normal basal LH (<10 IU/ml) - Normal basal estradiol (<80 pg/ml) Exclusion Criteria: - Poor responder patients - Polycystic ovaries |
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
Greece | Eugonia | Athens |
Lead Sponsor | Collaborator |
---|---|
Eugonia |
Greece,
Lainas T, Zorzovilis J, Petsas G, Stavropoulou G, Cazlaris H, Daskalaki V, Lainas G, Alexopoulou E. In a flexible antagonist protocol, earlier, criteria-based initiation of GnRH antagonist is associated with increased pregnancy rates in IVF. Hum Reprod. 2005 Sep;20(9):2426-33. Epub 2005 Jun 9. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Ongoing pregnancy per embryo transfer | |||
Secondary | Biochemical pregnancy per embryo transfer | |||
Secondary | Clinical pregnancy per embryo transfer | |||
Secondary | Embryological data |
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