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Infertility clinical trials

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NCT ID: NCT05948293 Withdrawn - Infertility Clinical Trials

FSH Doser for Controlled Ovarian Stimulation

ALGO3
Start date: June 2024
Phase: N/A
Study type: Interventional

The study aims to evaluate the effectiveness of an individualized FSH dosing model called IDoser in controlled ovarian stimulation (COS) for assisted reproduction. The randomized, controlled, multicenter trial involves 236 first cycle IVF patients, who will be assigned to either the intervention arm (using the IDoser model) or the control arm (standard clinician-determined dosing). The primary outcome is the number of mature oocytes retrieved, with the hypothesis of non-inferiority for the intervention arm. Secondary outcomes include cycle cancellations, risk of ovarian hyperstimulation syndrome (OHSS), and pregnancy and live birth rates.

NCT ID: NCT05571111 Withdrawn - Infertility Clinical Trials

Clinical Research Study to Learn About the Effect and Safety of Different Doses of FE 999302 When Given as a Single Dose for Final Development of the Eggs After Ovarian Stimulation

TIFFANY
Start date: October 4, 2022
Phase: Phase 2
Study type: Interventional

The primary purpose of this trial is to compare three different doses of FE 999302 with 250 µg OVITRELLE and 10,000 IU NOVAREL on oocyte maturity when administered as a single dose for final development of the oocytes in women undergoing controlled ovarian stimulation.

NCT ID: NCT05048511 Withdrawn - Infertility Clinical Trials

Impact of Vitamine D Status on in Vitro Fertilization Outcomes

DFIV
Start date: January 1, 2016
Phase:
Study type: Observational

Non skeletal effect of vitamin D have been the focus of much interest in the past decade. During the last years, special attention has been given to the impact of vitamin D on human reproduction. Its receptor is expressed in most reproductive organs including hypothalamus, pituitary gland, uterus, ovary, mammary gland and the placenta. In vitro experiments suggest that vitamin D would be involved in regulated embryo-implantation. Concerning AMH, vitamin D seems to alters AMH signaling in human granulosa cells although their circulated levels are correlated in lated reproductive aged women. The results of precedents studies about the impact of vitamin D on IVF outcomes remain conflicting The aim of our study was to assess in a large unselected population of infertile women, the impact of vitamin D deficiency on IVF outcome and to examine the relationship between serum vitamin D levels and the ovarian reserve marker AMH.

NCT ID: NCT05004870 Withdrawn - Fertility Issues Clinical Trials

Home Examinations Researching and Understanding Submucosal Evaluations

HER-USE
Start date: December 16, 2021
Phase: N/A
Study type: Interventional

To demonstrate that imaging via home ultrasound can identify submucosal fibroids. The image quality and submucosal fibroid detection specificity of the home imaging has already been demonstrated; the aim of this study is to generate further data for sensitivity. This will be a single visit study, with participants scanning themselves at home with healthcare professional (HCP) supervision. Targeted population is women with previously diagnosed submucosal fibroids that have not been removed. The study will be single-blinded to the image raters.

NCT ID: NCT04955574 Withdrawn - Endometriosis Clinical Trials

Probiotic and Antibiotic Therapies in Women With Unexplained Infertility

Start date: January 2023
Phase: Phase 2
Study type: Interventional

The study is designed as a proof of concept pilot study with 3 study arms to evaluate the safety and feasibility of the use of oral probiotics and/or antibiotics in women with unexplained infertility/endometriosis. Our secondary outcomes will assess In Vitro Fertilization outcomes, and changes in the uterine microbiota (bacteria), intestinal barrier integrity, and urinary metabolites in response to study interventions.

NCT ID: NCT04814940 Withdrawn - Infertility, Female Clinical Trials

Retrospective Analysis of Real-world Data From Medical Records on the Use of MENOPUR for Infertility Treatment

Start date: September 1, 2022
Phase:
Study type: Observational

The purpose of this retrospective observational study is to describe the treatment patterns with MENOPUR and to understand the clinical impact for patients that underwent infertility treatment under real-world setting. The primary objective is to describe the treatment patterns for the general population and for selected patient profiles.

NCT ID: NCT04753736 Withdrawn - Infertility, Female Clinical Trials

Immunophenotypage of RIF and RM Patients and Intrauterine Administration of PBMC

Start date: September 24, 2021
Phase: N/A
Study type: Interventional

The purpose of this study is to identify a systemic immunological profile specific to patients with recurrent implantation failures (RIF) or miscarriages (RM) through blood immunophenotyping on the day of ovulation. This study also aims to determine whether the intrauterine administration of 5 million peripheral blood monocluear cells increases implantation and pregnancy rates in patients with RIF and decreases the risk of miscarriages in patients with RM, compared to what has already been published in the scientific literature

NCT ID: NCT04717362 Withdrawn - Infertility, Male Clinical Trials

The Effects of Natesto For Treatment Of Hypogonadism

Start date: March 1, 2024
Phase: Early Phase 1
Study type: Interventional

In this prospective study, the investigators plan is to confirm the role of Natesto (intranasal testosterone) to combat hypogonadal symptoms in men trying to recover spermatogenesis following the withdrawal of conventional Testosterone replacement therapy.

NCT ID: NCT04711239 Withdrawn - Clinical trials for Secondary Infertility

Non-invasive Preimplantation Genetic Testing for Aneuploidies Using Cell-free DNA in Spent Culture Media

niPGT-A
Start date: October 15, 2021
Phase:
Study type: Observational

Analysis of embryonic cell-free DNA (cfDNA) present in the spent culture media (SCM) is a non-invasive alternative for preimplantation genetic testing for aneuploidies (PGT-A) that avoids the technical challenges and limitations of biopsy. Initial studies investigating this non-invasive PGT-A (niPGT-A) method reported variable concordance between cfDNA in SCM and the trophectoderm sample (~ 30%-86%) and indicated a contribution from both the inner cell mass and trophectoderm to the cfDNA in SCM. This study aims to evaluate the use of the embryo culture medium as a source of genetic material for PGT-A and validate a niPGT-A protocol using cfDNA in SCM.

NCT ID: NCT04683237 Withdrawn - Obese Clinical Trials

Liraglutide Plus Megestrol Acetate in Endometrial Atypical Hyperplasia

Start date: March 20, 2021
Phase: Phase 2/Phase 3
Study type: Interventional

To investigate the efficacy of liraglutide plus megestrol acetate in obesity patients with atypical endometrial hyperplasia (AEH)