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Unraveling the Klinefelter's Disease Physiopathology — KLINEFELTER  

Infertility, Male Clinical Trial

Official title:
Unraveling the Klinefelter's Disease Physiopathology by Organoid Model

Clinical Trial Summary

Organoid Model to unravel Klinefelter Syndrome infertility Klinefelter Syndrome (KS) is characterized by the presence of an extra chromosome X in male (47,XXY), it is the most frequent genetic cause of azoospermia in adult men. The investigators will isolate and expand spermatogonial cells from KS patients, then using an organoid model investigators will compare the behavior of these Spermatogonia from KS patients when interacting with four combinations of somatic cell types incorporated in the Extra Cellular Matrix hydrogel.

Clinical Trial Description

Men with Klinefelter Syndrome candidate for TESE or microTESE (testicular sperm extraction) for azoospermia. One extra testicular biopsy (1-2 mm) will be cryopreserved and used later for the cells isolation and culture. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05997706
Study type Interventional
Source Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Contact Christine Wyns, MD, PhD
Phone +3227649501
Email christine.wyns@uclouvain.be
Status Recruiting
Phase N/A
Start date June 12, 2018
Completion date April 1, 2025
View Details
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