Comparison of the Effect of Microchip & Density Gradient Methods in

Status Recruiting

Clinical Trial Summary

Microfluidic chips are one of the methods of sperm separation to eliminate DNA fragmentation in sperm. It is thought that the separation of sperm by centrifugation in the classical gradient density (Percoll) method used in sperm separation in IVF and IUI cycles leads to the increase of reactive oxygen radicals in sperm and this leads to sperm DNA fragmentation. Studies comparing Percoll and microfluidic chip method in terms of sperm, embryo quality and pregnancy rates are limited. In this context, it is aimed to investigate the effect of Percoll or Microfluidic Chip Technology on the quality of sperms and embryos obtained with these sperms and their pregnancy rates prospectively.

Clinical Trial Description

The increase in infertility rate due to environmental and physiological conditions leads to an increase in the use of assisted reproductive techniques. Isolation of living and morphologically normal live sperm is an integrated procedure in commonly used IVF / ICSI(intracytoplasmic sperm injection) / IUI(intrauterine insemination) procedures. Although current IUI procedures result in a successful pregnancy of around 10-15%, the process can be greatly compromised if the selected sperm is abnormal. Microfluidic chips are one of the recommended sperm separation methods to eliminate DNA fragmentation in sperm. It is thought that the separation of the sperm by centrifugation in the classical gradient density (Percoll) method which is used in the separation of sperm in the IUI cycles, causes the increase of reactive oxygen radicals in sperm and this leads to sperm DNA fragmentation. Studies comparing Percoll and microfluidic chip method in terms of sperm, embryo quality and pregnancy rates are limited. In this context, it is aimed to investigate the effect of Percoll or Microfluidic Chip Technology on the quality of sperms and embryos obtained with these sperms and their pregnancy rates prospectively. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04144244
Study type	Interventional
Source	Bezmialem Vakif University
Contact	Pinar Ozcan, MD, Assoc Prof
Phone	+902124531700
Email	drpinarozcan@hotmail.com
Status	Recruiting
Phase	N/A
Start date	November 15, 2019
Completion date	July 15, 2020

View Details

See also
Status	Clinical Trial	Phase
Active, not recruiting	`NCT04142112` - Randomized, Standard-Controlled, Study to Evaluate the Ohana IVF Sperm Preparation Kit, SPeRtility IVF Next Generation	N/A
Recruiting	`NCT04955782` - Abstinence Period and Semen Quality
Recruiting	`NCT05506722` - Using of Testes Shocker in Improving the Spermatogenesis and Sperms Activity	N/A
Not yet recruiting	`NCT03988361` - Selection of Non Apoptotic Human Sperm for in Vitro Fertilization by Using Magnetic Activated Cell Sorting (MACS)
Completed	`NCT03319654` - Impact of DNA Fragmentation in Sperm on Pregnancy Outcome After Intra-uterine Insemination in a Spontaneous Cycle	N/A
Not yet recruiting	`NCT05597631` - G-IVF and Sperm Parameters	N/A
Completed	`NCT05919186` - Effects of Antioxidant Supplementation of Culture Media on IVF Embryos	N/A
Recruiting	`NCT03588949` - Role of Nutritional Support in Idiopathic Male Infertility	N/A
Recruiting	`NCT03527043` - Impact of Escitalopram on Sperm DNA Fragmentation	Phase 2
Not yet recruiting	`NCT06050031` - Level of DNA-fragmentation Before and After Antioxidant-based Therapies in Male Infertility
Completed	`NCT02932865` - Modern Analyses of the Semen in Evaluating Male Fertility and Treatment Options of Male Infertility
Completed	`NCT02310087` - Oral Astaxanthin and Semen Quality, Fertilization and Embryo Development in Assisted Reproduction Techniques Procedures	N/A
Completed	`NCT00385346` - Expressive Writing in Male Infertility	N/A
Completed	`NCT04509583` - The Role of Micro Nutrient Supplement in Improvement of the Sperm DNA Fragmentation	N/A
Recruiting	`NCT04452305` - Spermatogonial Stem Cell (SSC) Transplant and Testicular Tissue Grafting	N/A
Completed	`NCT05461079` - Sperm Phenotype and Differentially Methylated Regions
Recruiting	`NCT05205733` - Expanding Fertility Care to Poor and Low Resourced Settings Study	N/A
Completed	`NCT03960229` - The Evaluation of the Effect of Microfluidic Sperm Sorting Chip 'Labs-on-a-chip' on IVF Success in Male Factor	N/A
Not yet recruiting	`NCT03090438` - IVF Outcomes After Varicocele Repair	N/A
Recruiting	`NCT03968367` - To Study the Effect of Magnetic Activated Sperm Sorting on the Outcome of in Vitro Fertilization-embryo Transplantation	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Comparison of the Effect of Microchip and Density Gradient Methods in Intrauterine Insemination Cycles

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms