Infertility, Male Clinical Trial
Official title:
The Influence of Lead and Cadmium Seminal Plasma Level on Intracytoplasmic Sperm Injection (ICSI) Outcome
To evaluate the influence of lead (pb) and cadmium (cd) seminal plasma level on embryo development and pregnancy rate during intracytoplasmic sperm injection (ICSI).
The inability to have children, both by natural procreation and medically assisted reproduction, is not only a challenge for medical science but also an economic and social problem. Infertility is a complex disorder with multiple genetic and environmental causes (Gill et al.,2018) One of the factors that may be responsible for this phenomenon is contamination of the environment with heavy metals Two of the most widely-recognized reproductive toxins are lead (Pb) and cadmium (Cd) (Wdowiak et al., 2018). Food, water and tobacco and smoking are the primary source of baseline exposure to lead and cadmium (Tong et al., 2000; Bernard, 2008) Each of cadmium and lead were inversely correlated with semen parameters as, ejaculate volume, sperm count, sperm concentration, live sperms and rapid mobility. ( Zaki et al.,2018). Reproductive contaminants found in follicular fluid (FF) and seminal plasma may compromise the quality of oocytes and or sperm, which may become one of the risk factors for reproductive outcome. The data available suggests certain chemicals or their metabolite reaches the seminal plasma and/or FF, indicating their possible impact in In Vitro fertilization (IVF) outcome ,However, more studies are needed with regard to relationship between exposure level and affected parameters. (Kumar et al., 2010). ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Active, not recruiting |
NCT04142112 -
Randomized, Standard-Controlled, Study to Evaluate the Ohana IVF Sperm Preparation Kit, SPeRtility IVF Next Generation
|
N/A | |
| Recruiting |
NCT04955782 -
Abstinence Period and Semen Quality
|
||
| Recruiting |
NCT05506722 -
Using of Testes Shocker in Improving the Spermatogenesis and Sperms Activity
|
N/A | |
| Not yet recruiting |
NCT03988361 -
Selection of Non Apoptotic Human Sperm for in Vitro Fertilization by Using Magnetic Activated Cell Sorting (MACS)
|
||
| Completed |
NCT03319654 -
Impact of DNA Fragmentation in Sperm on Pregnancy Outcome After Intra-uterine Insemination in a Spontaneous Cycle
|
N/A | |
| Not yet recruiting |
NCT05597631 -
G-IVF and Sperm Parameters
|
N/A | |
| Completed |
NCT05919186 -
Effects of Antioxidant Supplementation of Culture Media on IVF Embryos
|
N/A | |
| Recruiting |
NCT03588949 -
Role of Nutritional Support in Idiopathic Male Infertility
|
N/A | |
| Recruiting |
NCT03527043 -
Impact of Escitalopram on Sperm DNA Fragmentation
|
Phase 2 | |
| Not yet recruiting |
NCT06050031 -
Level of DNA-fragmentation Before and After Antioxidant-based Therapies in Male Infertility
|
||
| Completed |
NCT02932865 -
Modern Analyses of the Semen in Evaluating Male Fertility and Treatment Options of Male Infertility
|
||
| Completed |
NCT02310087 -
Oral Astaxanthin and Semen Quality, Fertilization and Embryo Development in Assisted Reproduction Techniques Procedures
|
N/A | |
| Completed |
NCT00385346 -
Expressive Writing in Male Infertility
|
N/A | |
| Completed |
NCT04509583 -
The Role of Micro Nutrient Supplement in Improvement of the Sperm DNA Fragmentation
|
N/A | |
| Recruiting |
NCT04144244 -
Comparison of the Effect of Microchip and Density Gradient Methods in Intrauterine Insemination Cycles
|
N/A | |
| Recruiting |
NCT04452305 -
Spermatogonial Stem Cell (SSC) Transplant and Testicular Tissue Grafting
|
N/A | |
| Completed |
NCT05461079 -
Sperm Phenotype and Differentially Methylated Regions
|
||
| Recruiting |
NCT05205733 -
Expanding Fertility Care to Poor and Low Resourced Settings Study
|
N/A | |
| Completed |
NCT03960229 -
The Evaluation of the Effect of Microfluidic Sperm Sorting Chip 'Labs-on-a-chip' on IVF Success in Male Factor
|
N/A | |
| Not yet recruiting |
NCT03090438 -
IVF Outcomes After Varicocele Repair
|
N/A |