Preimplantation Genetic Screening in Patients With Male Factor Infertility

Status Recruiting

Clinical Trial Summary

This will be a prospective, randomized (1:1 ratio) clinical trial for patients with severe male-factor infertility with or without preimplantation genetic screening (PGS). Qualified 450 patients are randomized into either of two groups: group A will undergo intracytoplasmic sperm injection (ICSI) without PGS (225 cases), Group B will undergo ICSI with PGS (225 cases). The partners of all participants will receive the same protocol for ovarian stimulation and standardized luteal phase support. The target population will be patients with severe male-factor infertility aged between 20 and 55 years, diagnosed by the ESHER Criteria (Non-obstructive oligospermia，asthenspermia). Women with other reasons of infertility (eg. advanced age, anovulation, endometriosis, and premature ovarian failure) are excluded. The randomization will take place 3-6 days after the oocyte pick-up day by a computer randomization system. The pregnancy test results, pregnancy complications, congenital anomalies, neonatal complications will be followed up by checking medical records and telephone calls.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02941965
Study type	Interventional
Source	International Peace Maternity and Child Health Hospital
Contact	He-Feng Huang, MD
Phone	+86-21-18017310186
Email	hefenghuang@126.com
Status	Recruiting
Phase	N/A
Start date	July 18, 2017
Completion date	June 30, 2023

View Details

See also
Status	Clinical Trial	Phase
Active, not recruiting	`NCT04142112` - Randomized, Standard-Controlled, Study to Evaluate the Ohana IVF Sperm Preparation Kit, SPeRtility IVF Next Generation	N/A
Recruiting	`NCT04955782` - Abstinence Period and Semen Quality
Recruiting	`NCT05506722` - Using of Testes Shocker in Improving the Spermatogenesis and Sperms Activity	N/A
Not yet recruiting	`NCT03988361` - Selection of Non Apoptotic Human Sperm for in Vitro Fertilization by Using Magnetic Activated Cell Sorting (MACS)
Completed	`NCT03319654` - Impact of DNA Fragmentation in Sperm on Pregnancy Outcome After Intra-uterine Insemination in a Spontaneous Cycle	N/A
Not yet recruiting	`NCT05597631` - G-IVF and Sperm Parameters	N/A
Completed	`NCT05919186` - Effects of Antioxidant Supplementation of Culture Media on IVF Embryos	N/A
Recruiting	`NCT03588949` - Role of Nutritional Support in Idiopathic Male Infertility	N/A
Recruiting	`NCT03527043` - Impact of Escitalopram on Sperm DNA Fragmentation	Phase 2
Completed	`NCT02932865` - Modern Analyses of the Semen in Evaluating Male Fertility and Treatment Options of Male Infertility
Completed	`NCT02310087` - Oral Astaxanthin and Semen Quality, Fertilization and Embryo Development in Assisted Reproduction Techniques Procedures	N/A
Completed	`NCT00385346` - Expressive Writing in Male Infertility	N/A
Completed	`NCT04509583` - The Role of Micro Nutrient Supplement in Improvement of the Sperm DNA Fragmentation	N/A
Recruiting	`NCT04144244` - Comparison of the Effect of Microchip and Density Gradient Methods in Intrauterine Insemination Cycles	N/A
Recruiting	`NCT04452305` - Spermatogonial Stem Cell (SSC) Transplant and Testicular Tissue Grafting	N/A
Completed	`NCT05461079` - Sperm Phenotype and Differentially Methylated Regions
Recruiting	`NCT05205733` - Expanding Fertility Care to Poor and Low Resourced Settings Study	N/A
Completed	`NCT03960229` - The Evaluation of the Effect of Microfluidic Sperm Sorting Chip 'Labs-on-a-chip' on IVF Success in Male Factor	N/A
Not yet recruiting	`NCT06050031` - Level of DNA-fragmentation Before and After Antioxidant-based Therapies in Male Infertility
Not yet recruiting	`NCT03090438` - IVF Outcomes After Varicocele Repair	N/A