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NCT05577806 Clinical Trial

DYG Versus Cetrorelix in Oocyte Donation

Infertility, Female Clinical Trial

Official title:
Comparison of Reproductive Outcomes After Progestin-primed Ovarian Stimulation With Dydrogesterone Versus Cetrorelix to Inhibit Spontaneous Ovulation in Oocyte Donation

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT05577806
Other study ID # PPOS-DU-OD
Secondary ID
Status Completed
Phase
First received
Last updated
Start date January 1, 2017
Est. completion date December 31, 2021

Study information
Verified date October 2022
Source Clinica de la Mujer Medicina Reproductiva, Chile
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Prospective controlled study to assess the reproductive outcomes of OD recipients in which the donors were subjected to the DYG protocol (20mg/day) compared with those subjected to the short protocol with cetrorelix (0.25 mg/day) from Day 7 or since a leading follicle reached 14 mm. The OD cycles were triggered with triptoreline acetate and the trigger criterion was ≥3 follicles of diameter >18mm.

Recruitment information / eligibility
Status Completed
Enrollment 202
Est. completion date December 31, 2021
Est. primary completion date December 31, 2021
Accepts healthy volunteers
Gender Female
Age group 21 Years to 30 Years
Eligibility Inclusion Criteria: - Oocyte donors between 21 and 30 years old, with regular menstrual cycles (24-35 d) and a body mass index (BMI) between 18 and 28 kg/m2 without any relevant personal or family history Exclusion Criteria: - AMH less than 3 ng/dL - A positive screening for sexually transmitted diseases

Study Design

Related Conditions & MeSH terms

Intervention

Drug:
• Dydrogesterone
progestin primed ovarian stimulation

Locations
Country Name City State
n/a

Sponsors (1)
Lead Sponsor Collaborator
Clinica de la Mujer Medicina Reproductiva, Chile

Outcome
Type Measure Description Time frame Safety issue
Primary Live Birth Rate per transfer 40 weeks after ET
Primary Clinical pregnancy per transfer 12 weeks after ET
Primary Miscarriage rate 12 weeks after ET
Secondary Number of oocytes retrieved at time of oocyte retrieval
Secondary Number of mature oocytes 1 day after IVF
Secondary Number of fertilized oocytes 1 day after IVF
Secondary Number of blastocists 5-6 days after OPU
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