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Infertility, Female clinical trials

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NCT ID: NCT06105593 Active, not recruiting - Infertility, Female Clinical Trials

Effect of Balneotherapy and Physiotherapy Treatment in Female Infertility: a Retrospective Study

Start date: September 1, 2023
Phase:
Study type: Observational

The goal of this observational study is to assess the effect of complex balneotherapy and physiotherapy treatment among infertile women treated in the Harkany Thermal Rehabilitation Center between July 01, 2007 and December 31, 2021. The main questions it aims to answer are: - To what extent can the complex balneotherapy and physiotherapy treatment be an effective additional therapy in female infertility? - What are the clinical changes behind infertility that can be helped by the complex balneotherapy and physiotherapy treatment? Participants will be asked to answer a questionnaire that we have prepared.

NCT ID: NCT05638529 Active, not recruiting - Infertility, Female Clinical Trials

Dual Trigger" in IVF Patients at High Risk of Ovarian Hyper Stimulation Syndrome

Start date: May 1, 2019
Phase: Phase 4
Study type: Interventional

The present study aims to evaluate whether the use of a "dual trigger" can improve IVF outcomes, compared to GnRH agonist (GnRH-a) alone, in patients at high risk of OHSS undergoing a freeze-all cycle. By examining freeze-all cycles with frozen embryo transfer(s) (FET) only, we eliminate the potential confounding issue of inadequate luteal support to the endometrium and focus primarily on the effect of a "dual trigger" on oocyte quality and embryo potential. To our best knowledge, there have been no randomized, controlled trials conducted to address this hypothesis.

NCT ID: NCT05633316 Active, not recruiting - Infertility, Female Clinical Trials

Automated Intracytoplasmic Sperm Injection (ICSIA)

ICSIA
Start date: December 5, 2022
Phase: N/A
Study type: Interventional

The purpose of this research study is to evaluate Overture's automated Intracytoplasmic Sperm Injection (ICSIA) System. ICSIA is an investigational medical device that automates injection of sperm into eggs. This study will evaluate survival and fertilization rates of oocytes handled via ICSIA and compare to survival and fertilization rates of oocytes which are manually injected with sperm.

NCT ID: NCT05397912 Active, not recruiting - Infertility, Female Clinical Trials

Uterine Elastography: a Potential Predictor of Embryo Transfer Success

Start date: June 15, 2022
Phase:
Study type: Observational

To determine if the mean elasticity value (measured in kilopascals, kPa) of a patient's endometrium, myometrium and cervix in a sonographically normal appearing uterus predict frozen embryo transfer (FET) success and long term reproductive outcomes when measured the day prior to FET.

NCT ID: NCT05266924 Active, not recruiting - Female Infertility Clinical Trials

Recombinant Follicle-stimulating Hormone in Treatment for Infertility

REFRESH
Start date: July 23, 2022
Phase: Phase 3
Study type: Interventional

This is a randomized multi-centre, assessor-blind, parallel-group study to be conducted in 250 women in the age group of 20 to 39 years (both inclusive), who are indicated to undergo COS as part of assisted reproductive technology (ART). The participant will receive r-hFSH, fixed-dose for 5 days, and day 6 onwards the dose may be adjusted for a single cycle of COS followed by ART procedures, and post-ART follow-up for ongoing pregnancy. The primary and secondary outcomes will be captured on days as per protocol. Adverse events will be noted for safety evaluation.

NCT ID: NCT05026619 Active, not recruiting - Anxiety Clinical Trials

Youth Outlook on Life Opportunities Study

Start date: September 21, 2021
Phase: N/A
Study type: Interventional

Singapore's fertility rate is currently below 1.2, raising concerns about population ageing and long-term sustainability. The fertility decline is characterized by falling birth rates among women in their 20s with almost no recuperation among women in their 30s. This project explores a) whether informational imperfections help to account for high intended ages at childbearing in Singapore, b) whether informational interventions significantly affect ideal and expected ages at marriage and childbearing, and expected probability of undergoing social egg freezing, and c) whether informational interventions significantly affect expected and actual educational outcomes and labor market outcomes. Our hypotheses are: 1. University students have knowledge gaps about age-related onset of infertility, assisted reproductive technologies and local policy initiatives related to age at marriage and childbearing, especially among male students. 2. Being exposed to accurate information in these domains leads to significantly lower ideal/expected ages at marriage and childbearing, and higher expected probability of undergoing social egg freezing, immediately after the intervention. 3. Being exposed to accurate information in these domains does not lead to lower educational and labor market expectations immediately after the intervention among either male or female students, or to significant differences in module choices, Cumulative Average Point (CAP), starting salary and employment status of university students in the following academic semester and six months after graduation, among either male or female students.

NCT ID: NCT04865367 Active, not recruiting - Infertility Clinical Trials

How Secreted-embryo-derived Trypsin Initiates, Maintains and Terminates Ca2+ Signals in Uterine Epithelial Cells

Ca2+
Start date: November 4, 2021
Phase:
Study type: Observational

To develop a deeper understanding of endometrial-embryo crosstalk through basic research, uncover therapeutic targets and to improve reproductive outcome.

NCT ID: NCT04330066 Active, not recruiting - Infertility, Female Clinical Trials

Impact of Endometrial Compaction in Euploid Frozen Embryo Transfers

Start date: September 1, 2020
Phase:
Study type: Observational

The purpose of this pilot study is to evaluate whether a decrease in endometrial thickness (compaction) prior to progesterone exposure (endogenous or exogenous) to the day before a single frozen embryo transfer has an impact on the clinical pregnancy rate with euploid embryos in exogenous hormone and modified natural thaw cycles. Information derived from this study may give insight on ways to improve pregnancy rates in cryo-thaw cycles.

NCT ID: NCT04168567 Active, not recruiting - Infertility, Female Clinical Trials

The Impact of Body Mass Index in the Endometrial Microbiome in IVF Treatments

Start date: August 14, 2020
Phase: N/A
Study type: Interventional

This study is a prospective trial with 90 patients suffering from the male type infertility. Patients are divided in two groups (45 patients per group) on the grounds of body mass index (BMI). .

NCT ID: NCT04166825 Active, not recruiting - Endometriosis Clinical Trials

Ovarian Hyperstimulation and Fibrin Clot Properties.

Start date: November 18, 2019
Phase: N/A
Study type: Interventional

The impact evaluation of ovarian hyperstimulation on coagulation and fibrinolysis in infertile women. Comparative analysis between different ovarian stimulation protocols on thrombin formation and efficiency of fibrinolysis in women diagnosed with infertility.