Infertility, Female, Associated With Anovulation Clinical Trial
Official title:
Intrauterine Infusion of Autologous Platelet-rich Plasma to Prevent a Thin Endometrium in Infertile Women Undergoing Clomiphene Citrate Therapy: a Pilot Prospective Self-controlled Trial
This is a prospective self-controlled clinical study. Women with clomiphene Citrate failure with thin endometrium less than 7 millimeters for at least 3 cycles will be selected (N = 30). Patients will receive 2 ovarian stimulation cycles with Clomiphene citrate (CC) 100 mg/ day for 5 days from cycle day 3. A control cycle (CC only cycle) woman will continue on CC alone plus cervical irrigation of cervix with 1 ml of 0.9% normal saline at cycle day 8 and 10 to assure patient-blinded method. The study group, the same will be done plus the intrauterine infusion of Autologous platelet-rich plasma (PRP) in 8th and 10th days of the cycle. In both groups, the endometrial thickness and Power Doppler evaluation of their endometrial and sub-endometrial blood flow will be measured on the day of Human Chorionic Gonadotropin (HCG) administration.
This is a pilot prospective self-controlled clinical trial. Women with Clomiphene Citrate
failure with documented thin endometrium less than 7 millimeters for at least 3 stimulation
cycles will be chosen (N = 30). Patients will experience 2 ovarian stimulation cycles with
Clomiphene citrate (CC) in a dose of 100 mg/ day for 5 days starting from cycle day 3. A
control cycle (CC only cycle) woman will continue on Clomiphene Citrate alone plus cervical
irrigation of cervix with 1 ml of 0.9% normal saline at cycle day 8 and 10 to confirm
patient-blinded process.
The study group, the same will be done in addition to the intrauterine infusion of with
Autologous platelet-rich plasma (PRP) in 8th and 10th days of the cycle.
In both groups, the endometrial thickness and Power Doppler evaluation of their endometrial
and sub-endometrial blood flow will be measured on the day of HCG administration.
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