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NCT01878721 Clinical Trial

Positron Emission Tomography of Infection and Vasculitis

Infection Clinical Trial

— PETU  

Official title:
Positron Emission Tomography of Infection and Vasculitis (PETU)

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT01878721
Other study ID # 14824
Secondary ID
Status Completed
Phase
First received
Last updated
Start date January 2011
Est. completion date October 2021

Study information
Verified date October 2021
Source Turku University Hospital
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The purpose of this study is to evaluate the value of positron emission tomography/computed tomography in various inflammatory conditions caused by bacterial infection or vasculitis. Glucose analog FDG is sensitive to detect inflammation foci but we hypothesize that other imaging agents such as PK11195 and Ga-citrate may have added value in certain applications.

Description:

The purpose of this study is to evaluate the value of PET/CT in various inflammatory conditions caused by bacterial infection or vasculitis. Our aim is to: 1. investigate whether FDG (18F-2-fluoro-2-deoxy-D-glucose fluorodeoxyglucose) PET/CT and 68Ga-(Gallium-68) citrate PET/CT enable the early and accurate detection of metastatic infection foci in Staphylococcus aureus bacteremia. 2. study the usefulness of FDG PET/CT in detection of endovascular infection in bacteremia caused by Salmonella spp. 3. find an optimal FDG PET/CT protocol for detection of infectious endocarditis and metastatic infection foci related to endocarditis. 4. study the value of FDG PET/CT in the diagnosis of infection of pacemaker or implantable cardioverter defibrillator. 5. investigate the usefulness of FDG PET/CT, 68Ga-citrate PET/CT, and 11C- (carbon-11) translocator protein ligand (PK11195) PET/CT in diagnosis of vasculitis and in imaging of the magnitude of the vascular changes.

Recruitment information / eligibility
Status Completed
Enrollment 117
Est. completion date October 2021
Est. primary completion date October 2021
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: Adults with - Staphylococcus aureus bacteremia or - Salmonella spp. bacteremia or - infective endocarditis or - infection of pacemaker or implantable cardioverter defibrillator or - vasculitis Exclusion Criteria: - underage, pregnant, breastfeeding, handicapped or prisoner

Study Design

Related Conditions & MeSH terms

Intervention

Radiation:
• PET/CT
positron emission tomography/computed tomography

Locations
Country Name City State
Finland Turku University Hospital Turku

Sponsors (1)
Lead Sponsor Collaborator
Turku University Hospital

Country where clinical trial is conducted

Finland, 

Outcome
Type Measure Description Time frame Safety issue
Primary Detection of infection or vasculitis in PET images within 1 week after starting the treatment
Secondary Standardized uptake value of PET imaging agent at the site of infection or vasculitis within 1 week after starting the treatment
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