Infection Clinical Trial
Official title:
Characterization of the Involvement of Translation Initiation Factors in the Immune Response to Acute Infection in the Elderly and Very Elderly
The investigators propose that the translation initiation factors eIF4E and eIF4GI may be
involved in resolution of acute inflammation (regardless of age). Furthermore, the
investigators suggest that differences in translation initiation factors state of activation
may contribute to inflammation. Finally, the investigators hypothesize that differences in
translation initiation factors state of activation may underlie the immune compromised state
of the very elderly affording additional explanation for the heightened morbidity from
infection in this group.
In the current study the investigators aim to test these hypotheses by measuring the levels
of eIF4E and eIF4G, their regulators, and targets in elderly (65-84yrs) and very elderly
(85yrs<) patients hospitalized at Meir hospital for acute infection and after their recovery
(detailed in study design).
Status | Recruiting |
Enrollment | 40 |
Est. completion date | October 2012 |
Est. primary completion date | October 2011 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 65 Years and older |
Eligibility |
Inclusion Criteria: - elderly patients (65<) - hospitalized for acute infection (fever 38c<, leukocytosis) Exclusion Criteria: - patients with dementia who can not sign informed consent of institutional Helsinki committee - patient with active cancer with active chemotherapy treatment |
Observational Model: Case-Only, Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
Israel | Meir Medical Center | Kfar Sava |
Lead Sponsor | Collaborator |
---|---|
Meir Medical Center |
Israel,
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