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NCT01215604 Clinical Trial

Involvement of Translation Initiation Factors in the Immune Response in the Elderly

Infection Clinical Trial

Official title:
Characterization of the Involvement of Translation Initiation Factors in the Immune Response to Acute Infection in the Elderly and Very Elderly

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT01215604
Other study ID # MMC10156-2010CTIL
Secondary ID
Status Recruiting
Phase N/A
First received October 5, 2010
Last updated March 16, 2012
Start date October 2010
Est. completion date October 2012

Study information
Verified date March 2012
Source Meir Medical Center
Contact n/a
Is FDA regulated No
Health authority Israel: The Israel National Institute for Health Policy Research and Health Services Research
Study type Observational

Clinical Trial Summary

The investigators propose that the translation initiation factors eIF4E and eIF4GI may be involved in resolution of acute inflammation (regardless of age). Furthermore, the investigators suggest that differences in translation initiation factors state of activation may contribute to inflammation. Finally, the investigators hypothesize that differences in translation initiation factors state of activation may underlie the immune compromised state of the very elderly affording additional explanation for the heightened morbidity from infection in this group.

In the current study the investigators aim to test these hypotheses by measuring the levels of eIF4E and eIF4G, their regulators, and targets in elderly (65-84yrs) and very elderly (85yrs<) patients hospitalized at Meir hospital for acute infection and after their recovery (detailed in study design).

Recruitment information / eligibility
Status Recruiting
Enrollment 40
Est. completion date October 2012
Est. primary completion date October 2011
Accepts healthy volunteers No
Gender Both
Age group 65 Years and older
Eligibility Inclusion Criteria:

- elderly patients (65<)

- hospitalized for acute infection (fever 38c<, leukocytosis)

Exclusion Criteria:

- patients with dementia who can not sign informed consent of institutional Helsinki committee

- patient with active cancer with active chemotherapy treatment

Study Design

Observational Model: Case-Only, Time Perspective: Prospective

Related Conditions & MeSH terms

Locations
Country Name City State
Israel Meir Medical Center Kfar Sava

Sponsors (1)
Lead Sponsor Collaborator
Meir Medical Center

Country where clinical trial is conducted

Israel, 

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