Infection Clinical Trial
Official title:
Reduction of Nosocomial VRE Colonization and Infection by Active Surveillance and Intervention of Infection Control (no)
Vancomycin -resistant enterococci(VRE) has emerged as one of the most common nosocomial
pathogen of health-care associated infection since 1988. Although the new antimicrobial
agents such as Tigecycline , Daptomycin, Linezolid have clinically effectiveness for the
treatment of VRE, but there was not appropriate drugs for eradicating the colonization of
VRE. So the active surveillance and strict contact precaution are the best methods for VRE
colonization and transmission.
This is a one year study program, we select a unit as the study site. First month (January)
is the prepare period. Therefore , we collect 3 months (from February to April) baseline
data, then interrupted one month(May) for the health care worker's infection control
education.
Then the intervention period are three months (from June to August), and the last four
months(from September to December) are the analysis and evaluation period. In the baseline
period, we only do the patient's active surveillance and environmental culture. In the
intervention period, beside the patient's active surveillance and environmental culture, we
add contact precaution as the infection control method. If patient has VRE infection, we
prescribe appropriate antibiotic therapy until the culture result proved no growth of VRE.
The aim of this study is to compare and analyze these two period (baseline period and
intervention period) for understanding the transmission, risk factors and carriage rate of
VRE, as the important guidelines for the VRE infection control in the future.
n/a
Observational Model: Case-Only
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