Infection Clinical Trial
Official title:
CD4 Count And Risk Of Infection In Patients With Brain Tumors
RATIONALE: Gathering information over time from laboratory tests of patients with newly
diagnosed malignant supratentorial astrocytoma may help doctors learn more about the effect
of treatment on white blood cell count and the risk of infection.
PURPOSE: This clinical trial is studying blood samples and risk of infection in patients
with newly diagnosed malignant supratentorial astrocytoma.
OBJECTIVES:
- Determine the frequency and severity of decreases in CD4 counts as a function of
therapy in patients with newly diagnosed malignant astrocytoma.
- Determine whether the decrease in CD4 counts is a significant predictor of infections
or adverse outcomes in these patients.
OUTLINE: This is a multicenter study.
Patients undergo monthly collection of blood for serial CD4 counts and heme-8 with
differential for 1 year for quantitative analysis. Patients also complete a monthly
questionnaire about infections and antibiotic use.
Patients are followed every 2 months.
PROJECTED ACCRUAL: A total of 125 patients (100 with high-grade disease and 25 with
low-grade disease) will be accrued for this study.
;
Observational Model: Case Control, Time Perspective: Prospective
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