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Infection clinical trials

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NCT ID: NCT04122495 Completed - Clinical trials for Respiratory Infection (for Example, Pneumonia, Bronchitis)

Treatment of Upper and Lower Respiratory Tract Infections in Young Children Using Probiotic

Start date: August 29, 2019
Phase: N/A
Study type: Interventional

This project aims to study the benefits of probiotics namely Bifidobacterium lactis M8 in treatment of upper and lower respiratory tract infections in young children, which are found common among children in Malaysia aged from 0-24 months.

NCT ID: NCT04120181 Completed - Infection Clinical Trials

A New Predictor Marker for Cochlear Implants Infection

Start date: May 2014
Phase:
Study type: Observational

Introduction: Surgical site infections associated with the cochlear implant can have serious consequences. Although advances in surgical techniques reduce these complications, it may be necessary to remove a device that works as a last resort as a result of ongoing infection. The removal of these devices, which are very expensive, increases the cost and takes the chance of hearing patients with this device. Therefore, it is very important to identify patients with a tendency to cochlear implant infection before surgery and to prevent these infections from occurring. Neutrophil/ lymphocyte ratio (NLR) and platelet/ lymphocyte ratio (PLR) are indicative of systemic inflammation and have a prognostic value in relation to mortality and morbidity in many diseases. The aim of this study was to identify patients with post-operative implant infection tendency in patients to be implanted with cochlear implant and to plan treatment for possible infections before cochlear implant, to reduce cost by preventing removal of implanted cochlear implant due to infection and to prevent the patient's chance of hearing through the cochlear implant from disappearing due to infection. Methods: In this retrospective study, 13 patients with cochlear implant infection were included. Preoperative NLR was calculated by dividing the neutrophil (NEU) value by the lymphocyte (LYM) value and preoperative PLR was calculated by dividing the NEU value by the LYM value.

NCT ID: NCT04117386 Completed - Pterygium Clinical Trials

Prevalence of HPV-associated Eye Infection and Cytokine Levels in Tears From Patients Diagnosed With Pterygium

Start date: January 1, 2020
Phase:
Study type: Observational

Prevalence of HPV-associated eye infection and cytokine levels in tears from patients diagnosed with pterygium

NCT ID: NCT04115423 Active, not recruiting - Clinical trials for Rheumatoid Arthritis

A Retrospective Cohort Study on the Risk of Serious Infections in Rheumatoid Arthritis Patients Receiving Tocilizumab

Start date: April 1, 2020
Phase:
Study type: Observational

The purpose of this study is to evaluate whether the risk of serious infections in rheumatoid arthritis patients with tocilizumab is higher than in those with tumor necrosis factor inhibitors using the nationwide real-world data.

NCT ID: NCT04111471 Recruiting - Clinical trials for Microbial Colonization

The Use of A Prebiotic to Promote a Healthy Gut Microbiome in Pediatric Stem Cell Transplant Recipients

Start date: October 31, 2019
Phase: N/A
Study type: Interventional

Children enrolled in the study will receive either the prebiotic inulin or a placebo for 21 days during the study period. They will start taking the product seven days before transplant starts until 14 days after transplant. Stool will be collected twice weekly until thirty days after transplant or discharge, whichever occurs first. Stool samples will be sampled for metagenomic sequencing to identify the diversity of bacteria within the stool. They will also be analyzed for amount of short-chain fatty acid content (a breakdown product of inulin) as well as for presence of genes that confer antibiotic resistance. From 30 days after transplant until 100 days after transplant, two stool samples will be collected at regularly scheduled follow up appointments (near day 60 and day 100). No product (inulin or placebo) will be given during this time frame. The study period ends 100 days after transplant.

NCT ID: NCT04111367 Recruiting - Clinical trials for Hepatitis C Virus Infection

Study of Seraprevir in Combination With Sofosbuvir in Chronic Genotype 2,3,6 Hepatitis C Virus Infection Patients

Start date: April 3, 2019
Phase: Phase 2
Study type: Interventional

This study was to assess the safety and efficacy of Seraprevir in combination with sofosbuvir in patients with Hepatitis C (HCV) genotype2,3,6. Efficacy was assessed by the rate of sustained viral response (SVR) 12 weeks after the discontinuation of therapy (SVR12).

NCT ID: NCT04108637 Completed - Infection Clinical Trials

Allergy Antibiotics And Microbial Resistance

ALABAMA
Start date: July 4, 2019
Phase: N/A
Study type: Interventional

ALBAMA study is designed to find out if the effects of Penicillin allergy assessment pathway (PAAP) intervention is on penicillin prescribing

NCT ID: NCT04107194 Recruiting - Clinical trials for Helicobacter Pylori Infection

Non-invasive Test-guided Tailored Therapy Versus Empiric Treatment for Helicobacter Pylori Infection.

THD-HP
Start date: January 14, 2020
Phase: Phase 3
Study type: Interventional

The aim of our study will be to assess in an open-label, multicenter, randomized controlled trial whether a tailored therapy guided by a non-invasive antibiotic susceptibility test on stool samples achieves higher Helicobacter eradication rates than an empiric antibiotic regimen. For this purpose, consecutive patients with dyspeptic symptoms, diagnosis of Helicobacter pylori infection and naïve to eradicating treatments will be allocated to either of the two intervention arms.

NCT ID: NCT04100980 Recruiting - Chronic UTI Clinical Trials

A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Chronic Urinary Tract Infections (UTI)

Start date: March 2, 2020
Phase:
Study type: Observational [Patient Registry]

Correlation of Microbiome to Chronic Urinary Tract Infections (UTI) via Relative Abundance Found in Microbiome Sequencing

NCT ID: NCT04100603 Recruiting - Clinical trials for Clostridium Difficile Infection

A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Clostridoides Difficile Infection

Start date: March 2, 2020
Phase:
Study type: Observational

This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records.