BPF Genetics of ILD Study

Idiopathic Pulmonary Fibrosis Clinical Trial

— BPF GILD  

Official title:

British Pigeon Fanciers Genetics of Interstitial Lung Disease Study

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT03747627
• Other study ID #: MS001
• Status: Active, not recruiting
• Start date: January 19, 2019
• Est. completion date: January 1, 2028

Study information

• Verified date: March 2024
• Source: University of Dundee
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational [Patient Registry]

Clinical Trial Summary

The investigators aim to examine the genetic determinants of interstitial lung disease in a cohort of subjects with regular exposure to pigeons, a known cause of one form of interstitial lung disease known as hypersensitivity pneumonitis. In addition we will examine immunological causes for hypersensitivity pneumonitis in this group. We anticipate our work will provide insights of use to clinicians and patients with hypersensitivity pneumonitis and other interstitial lung diseases.

Description:

The investigators aim to recruit participants with regular racing pigeon exposure at national (UK) and regional pigeon fancier meetings. Consenting subjects will complete questionnaires, provide blood samples for genetic analysis and immunological testing and undertake lung function measurements. Subjects will be observed, and encouraged to report referral to specialist respiratory services, and following this information will be sought on diagnosis (including supporting evidence). Where interstitial lung disease is detected this will be linked to subsequent unbiased analysis to detect potential predisposing genetic associations.

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 475
• Est. completion date: January 1, 2028
• Est. primary completion date: January 22, 2024
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 80 Years

Eligibility

Inclusion Criteria:

• regular exposure to racing pigeons

Exclusion Criteria:

• Unwilling to participate

Related Conditions & MeSH terms

• Alveolitis, Extrinsic Allergic
• Bird Fancier's Lung
• Fibrosis
• Idiopathic Interstitial Pneumonias
• Idiopathic Pulmonary Fibrosis
• Lung Diseases
• Lung Diseases, Interstitial
• Lung; Disease, Interstitial, With Fibrosis
• Pulmonary Fibrosis

Intervention

Diagnostic Test:
• Genetic profiling
All participating subjects will undergo detailed genetic analysis, with the aim of detecting novel genetic drivers for the development of interstitial lung disease in the context of known sensitising agent (pigeon antigen)

Locations

Country	Name	City	State
United Kingdom	Royal Pigeon Racing Association Meeting	Blackpool
United Kingdom	Scottish Homing Union	Lanark

Sponsors (6)

Lead Sponsor	Collaborator
University of Dundee	British Lung Foundation, British Pigeon Fanciers Medical Research, Newcastle University, University of Glasgow, University of Leicester

Country where clinical trial is conducted

United Kingdom, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Relationship of specific genetic markers to development of interstitial lung disease	Participants will be screened for MUC5B genetic profile to allow examination of MUC5B genetic profile relationship with risk of developing interstitial lung disease in this group	5 years