Idiopathic Pulmonary Fibrosis Clinical Trial
Official title:
Acute Effects of Oxygen Supplementation During Exercise Among Patients With Idiopathic Pulmonary Fibrosis Without Resting Hypoxemia
Idiopathic pulmonary fibrosis (IPF) is a disease characterised with significant morbidity and
poor prognosis. Dyspnoea and impaired exercise capacity are very common manifestations of the
disease, and result in significant impairment of patients' quality of life. Although
hypoxemia is common among subjects with IPF, published data on the effects of supplementary
oxygen therapy on specific clinical outcomes among these patients are currently few, while
the existing data on the potential benefits of oxygen supplementation to treat
exercise-induced hypoxemia, in this patient population, are even more controversial.
Based on the aforementioned, the purpose of this prospective, cross-over clinical trial is to
investigate the acute effects of supplemental oxygen administration on the: a) exercise
capacity, b) severity of dyspnea, c) cerebral oxygenation, b) muscle oxygenation, and e)
hemodynamic profile, as compared to delivery of medical air (sham oxygen), in a group of
patients with IPF, without resting hypoxemia, during steady state cardiopulmonary exercise
testing (CPET).
n/a
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